{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:20Z","timestamp":1747181960276,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulsed\u2010dye laser (PDL), as an effective and frequently\u2010used treatment modality for infantile hemangiomas (IH), could render patients at risk of developing long\u2010term alopecia. Data on alopecia caused by PDL treatment remain scant and the contributing factors are not clear. Our objective was to identify the risk factors associated with long\u2010term alopecia resulting from PDL treatment for scalp IH. We conducted a retrospective study incorporating patients with IH diagnosis and PDL intervention via thoroughly reviewing the clinical database of the dermatology department. Scalp IH patients were further screened and their medical records were collected. Long\u2010term alopecia was defined as no signs of terminal hair regrowth for at least 2\u00a0years in this study. Of the 1293 IH patients, 47 (14 boys and 33 girls) with a mean age of 4.5\u00a0months (standard deviation, 3.2) were diagnosed as scalp IH and had subsequently undergone PDL treatments. Hair growth in the treatment area of 18 patients (38.3%) nearly returned to normal, 22 patients (46.8%) had varying degrees of hair loss, and seven patients (14.9%) had no hair regrowth (long\u2010term alopecia). Compared with the older patients receiving treatment, IH patients younger than 3\u00a0months who started PDL treatment had a higher risk of developing long\u2010term alopecia (odds ratio, 30.833; 95% confidence interval, 4.079\u2013232.025; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). The total number of PDL sessions, post\u2010treatment blisters, and location of IH were not shown to be significantly associated with the development of long\u2010term alopecia. Collectively, our study provides an important insight into curating treatments for IH in infants younger than 3\u00a0months. PDL treatments for scalp IH may perhaps be avoided or delayed to prevent the development of treatment\u2010associated long\u2010term alopecia.<\/jats:p>","DOI":"10.1111\/1346-8138.16359","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T04:49:58Z","timestamp":1649220598000},"page":"661-665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors of long\u2010term alopecia after pulsed\u2010dye laser treatment for infantile scalp hemangiomas: A retrospective study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3833-9996","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology (HUST)  Wuhan China"},{"name":"Hubei Engineering Research Center for Skin Repair and Theranostics  Wuhan 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Medical College Huazhong University of Science and Technology (HUST)  Wuhan China"},{"name":"Hubei Engineering Research Center for Skin Repair and Theranostics  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology (HUST)  Wuhan China"},{"name":"Hubei Engineering Research Center for Skin Repair and Theranostics  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjie","family":"An","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology (HUST)  Wuhan China"},{"name":"Hubei Engineering Research Center for Skin Repair and Theranostics  Wuhan 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