{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:01:03Z","timestamp":1790614863356,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82003380"],"award-info":[{"award-number":["82003380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The exact efficacy of cyclosporine in the treatment of Stevens\u2013Johnson syndrome (SJS)\/toxic epidermal necrolysis (TEN) still needs evidence from more clinical data. This study was designed to compare the effectiveness and side\u2010effects of combined use of cyclosporine in the treatment TEN with glucocorticoids (GC)\/i.v. immunoglobulin G (IVIG). A total of 46 patients with SJS\/TEN were enrolled and classified into two groups based on the therapeutic drugs used. Clinical characteristics, interventions, outcomes, and disease progressions were collected and compared between the two groups. In our cohort, seven patients eventually died and the overall fatality rate was 15.2%, but there was no difference between the two groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.557). On discharge, the median SCORe of Toxic Epidermal Necrosis (SCORTEN) fell from 2.0 at admission to 1.0 and the median body surface area detached fell from 32.0% at admission to 9.5%. Patients in the cyclosporine group had a higher rate of re\u2010epithelialized area than patients in the non\u2010cyclosporine group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Cyclosporine significantly reduced the length of stay (19.0 vs. 13.0\u2009days, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019) and the rate of systemic infection (71.4% vs. 36.0%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017) compared with the non\u2010cyclosporine group. SCORTEN was the only significant risk factor for death and the risk ratio was 1.96 (1.17\u20133.31, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011). Conclusively, the combined use of cyclosporine could reduce the occurrence of systemic infection and accelerate the re\u2010epithelialization.<\/jats:p>","DOI":"10.1111\/1346-8138.16369","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T08:15:29Z","timestamp":1650356129000},"page":"629-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combined use of cyclosporine in the treatment of <scp>Stevens\u2013Johnson<\/scp> syndrome\/toxic epidermal necrolysis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4952-9274","authenticated-orcid":false,"given":"Rentao","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-017-8654-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.11.023"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.24748.1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.02.003"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0058"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.066"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.03.023"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14530"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-019-00275-0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2020.06.016"},{"key":"e_1_2_7_12_1","first-page":"E17","article-title":"Cyclosporine in SJS\/TEN management: a brief review","volume":"97","author":"Shokeen D","year":"2016","journal-title":"Cutis"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3731"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2018.12.018"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.044"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00061.x"},{"key":"e_1_2_7_17_1","volume-title":"Rule of nines. 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