{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:17:32Z","timestamp":1787494652979,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Many cases of bullous pemphigoid (BP) have been reported in patients taking dipeptidyl peptidase\u20104 inhibitors (DPP\u20104i), which are the most widely used antidiabetic drug for type 2 diabetes mellitus. However, no large\u2010scale survey has been conducted in Japan. This retrospective study investigated the incidence, clinical presentation, and clinical course of DPP\u20104i\u2010associated BP (DPP\u20104i\u2010BP) using epidemiological data from a nationwide registry for BP. In 2016, 713 new BP patients at 94 dermatological institutes were registered, 243 (34.1%) with DPP\u20104i\u2010BP and 461 (64.7%) with non\u2010DPP\u20104i\u2010BP. The male\u2010to\u2010female ratio was 1.9 and 0.84, respectively. Patients with DPP\u20104i\u2010BP were predominantly male. Non\u2010inflammatory BP was more common in DPP\u20104i\u2010BP (33.3%) than in non\u2010DPP\u20104i\u2010BP (14.6%), while inflammatory BP was common in both. No specific subtype or difference in disease severity was evident in DPP\u20104i\u2010BP. The most common gliptins administered to DPP\u20104i\u2010BP patients were vildagliptin (37.2%) and linagliptin (23.8%). DPP\u20104i intake was discontinued in 79.9% of cases after diagnosis. Some DPP\u20104i\u2010BP patients (17.6%) achieved spontaneous remission after discontinuing DPP\u20104i without requiring the use of systemic corticosteroids and\/or adjuvant therapy. Mean duration to achieve disease control was 2.87\u00a0months. The odds ratio for non\u2010inflammatory BP requiring systemic corticosteroids and\/or adjuvant therapy was low (0.52), suggesting that remission was achieved easily with supportive care in that phenotype. Non\u2010inflammatory and mild cases of DPP\u20104i\u2010BP may resolve spontaneously with supportive care, including the discontinuation of DPP\u20104i and no oral corticosteroid therapy.<\/jats:p>","DOI":"10.1111\/1346-8138.16394","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T01:18:45Z","timestamp":1651108725000},"page":"697-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical features of dipeptidyl peptidase\u20104 inhibitor\u2010associated bullous pemphigoid in Japan: A nationwide retrospective observational study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8041-3750","authenticated-orcid":false,"given":"Seiko","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School General Medical Center  Okayama Japan"},{"name":"Department of Dermatology Kawasaki Medical School  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7154-7033","authenticated-orcid":false,"given":"Takenobu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School General Medical Center  Okayama Japan"},{"name":"Department of Dermatology Kawasaki Medical School  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5575","authenticated-orcid":false,"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04062.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/25785826.2019.1619233"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.4556"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2352"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.045"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0210"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16479"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14601"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.038"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.05.043"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.13528"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.622"},{"key":"e_1_2_7_14_1","unstructured":"The 3rd NDB Open Data Japan website data from April 2016 to March 2017 published by the Ministry of Health Labour and Welfare. 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