{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:39:49Z","timestamp":1772210389654,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cancer\u2010associated hypercalcemia commonly occurs through abnormal secretions of parathyroid hormone\u2010related protein (PTHrP) from cancer cells. Several cases of PTHrP\u2010producing melanoma causing hypercalcemia have been reported; however, effective management of PTHrP\u2010producing BRAF wild\u2010type melanoma causing hypercalcemia after immune checkpoint inhibitor (ICI) failure is unclear. We report a case of PTHrP\u2010producing BRAF wild\u2010type melanoma leading to oncological emergency by hypercalcemia that was successfully treated with dacarbazine after ICI failure. A 65\u2010year\u2010old Japanese woman had advanced BRAF wild\u2010type melanoma that was refractory to ICI, and then led to hypoxia through exacerbated lung metastases and pleural effusion. Moreover, hypercalcemia appeared in parallel with increase of the serum PTHrP level. Dacarbazine was administered, and after the first administration, the pleural effusion was gradually decreased and hypoxia rapidly disappeared, and the serum calcium and PTHrP levels were improved within normal limits. Dacarbazine after ICI failure is potentially a useful option for oncological emergency due to progression of BRAF wild\u2010type melanoma including PTHrP\u2010producing types. Dacarbazine should be reevaluated as a therapeutic option for oncological emergency in patients with BRAF wild\u2010type melanoma after ICI failure.<\/jats:p>","DOI":"10.1111\/1346-8138.16411","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T09:15:06Z","timestamp":1651050906000},"page":"792-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful treatment with dacarbazine against a parathyroid hormone\u2010related protein\u2010producing melanoma causing hypercalcemia after immune checkpoint inhibitor failure"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-3316","authenticated-orcid":false,"given":"Yuma","family":"Waki","sequence":"first","affiliation":[{"name":"Department of Dermatology The Jikei University School of Medicine  Tokyo 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