{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:35:52Z","timestamp":1787506552758,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID\u201019) caused by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) was declared a pandemic by the World Health Organization, and COVID\u201019 continues to have a major impact on society. Numerous studies have reported impaired health sequelae after COVID\u201019 recovery, one of which is hair loss. Individuals with hair loss experience a substantial mental burden, which potentially hinders their social life. However, few studies have systematically analyzed the details including hair loss. Therefore, we conducted a narrative review using PubMed on the frequency, associated comorbidities, disease characteristics, and treatment of hair loss after SARS\u2010CoV\u20102 infection (HLASCI). Two search strings were used to identify 28 articles. Of note, most of the literature identified on COVID\u201019 sequelae reported an emergence\/occurrence of hair loss. HLASCI is speculated to be composed of a heterogeneous population, with the onset or exacerbation of telogen effluvium (TE), anagen effluvium, androgenetic alopecia (AGA), and alopecia areata (AA) reported as possible underlying mechanisms. Among these, acute TE is thought to be the primary cause of HLASCI, with COVID\u201019 treatment and TE improvement being considered crucial for HLASCI management. An association between COVID\u201019 and AA exacerbation has also been implicated with still insufficient evidence. Spontaneous recovery of TE can be expected once infection reduces; however, faster improvement in symptoms is expected to reduce the mental and social burden of patients. An additional search string identified 11 articles about TE treatment which suggested that the use of minoxidil may be beneficial. Topical minoxidil has been widely used for AGA patients, who have been speculated to exhibit poor resistance to SARS\u2010CoV\u20102. Topical minoxidil may provide relief from HLASCI, but future clinical research is warranted to confirm this observation.<\/jats:p>","DOI":"10.1111\/1346-8138.16475","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:58:55Z","timestamp":1653703135000},"page":"939-947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Management of hair loss after severe acute respiratory syndrome coronavirus 2 infection: Insight into the pathophysiology with implication for better management"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2662-5717","authenticated-orcid":false,"given":"Manabu","family":"Ohyama","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyorin University Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3700-182X","authenticated-orcid":false,"given":"Kiichi","family":"Matsudo","sequence":"additional","affiliation":[{"name":"Clinical Development, Research and Development Headquarters Self\u2010Medication Taisho Pharmaceutical Co.Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Fujita","sequence":"additional","affiliation":[{"name":"Clinical Development, Research and Development Headquarters Self\u2010Medication Taisho Pharmaceutical Co.Ltd  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.01.27.21250617"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000813"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.09.023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-021-00498-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14096"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13804"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13923"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2021.07.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517223"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11845\u2010021\u201002754\u20105"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14547"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15317"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1792400"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14136"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13948"},{"key":"e_1_2_8_17_1","first-page":"37","article-title":"Alopecia and severity of COVID\u201019: a cross\u2010sectional study in Peru","volume":"29","author":"Salazar Arenas MA","year":"2021","journal-title":"Infez Med"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.10.014"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5676"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14746"},{"key":"e_1_2_8_21_1","article-title":"Early antiandrogen therapy with dutasteride reduces viral shedding, inflammatory responses, and time\u2010to\u2010remission in males with COVID\u201019: a randomized, double\u2010blind, placebo\u2010controlled interventional trial (EAT\u2010DUTA AndroCoV trial \u2010 biochemical)","volume":"13","author":"Cadegiani FA","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13681"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13949"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.01.007"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3020013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.116731"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14761"},{"key":"e_1_2_8_28_1","first-page":"WE01","article-title":"Telogen effluvium: a review","volume":"9","author":"Malkud S","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.06.1009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14933"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17216"},{"key":"e_1_2_8_32_1","first-page":"37","article-title":"Biotin deficiency in telogen effluvium: fact or fiction?","volume":"13","author":"Abdel Rahman SH","year":"2020","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14413"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.5826\/dpc.1103a82"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13293"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.67.68"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13061"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13608"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14799"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14470"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700007"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05785.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.01.002"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.2217\/14750708.4.1.59"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16475","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16475","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:48:20Z","timestamp":1758721700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/1346-8138.16475"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16475","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,27]]},"assertion":[{"value":"2022-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}