{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:48:26Z","timestamp":1788648506968,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) is characterized by the activation of a cytokine storm derived from an excess release of cytokine (interleukin [IL]\u20106, interferon [IFN] I, C\u2010X\u2010C motif chemokine ligand [CXCL]10, tumor necrosis factor [TNF]\u2010\u03b1, macrophage inflammatory protein [MIP]1) due to an uncontrolled immune activation. There has been a fivefold increase in the number of cases of pityriasis rosea during the SARS\u2010CoV\u20102 pandemic. Using the keywords \u201cpityriasis\u201d and \u201cCOVID\u201019\u201d, we carried out a PubMed search, including all articles in the English language published until November 2021. We aimed to investigate the possible connection between SARS\u2010CoV\u20102 and pityriasis rosea (PR). Pityriasis could be considered an immunological disease due to the involvement of cytokines and chemokines. Our analysis yielded 65 articles of which 53 were not considered; the others (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) concerning the association between PR and COVID\u201019 were included in our study. We suggest two mechanisms underlying the involvement of the skin in viral infections: (i) viruses directly affecting the skin and\/or inducing host immune response thus causing cutaneous manifestations; and (ii) viruses as a possible inducer of the reactivation of another virus. The first mechanism is probably related to a release of pro\u2010inflammatory cytokine and infection\u2010related biomarkers; in the second, several pathways could be involved in the reactivation of other latent viruses (human herpesviruses 6 and 7), such as a cytokine\u2013cytokine receptor interaction, the Janus kinase\u2013signal transducer and activator of transcription signaling pathway, and the IL\u201017 signaling pathway. We thus believe that a cytokine storm could be directly or indirectly responsible for a cutaneous manifestation. More investigations are needed to find specific pathways involved and thus confirm our speculations.<\/jats:p>","DOI":"10.1111\/1346-8138.16482","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T14:19:15Z","timestamp":1654697955000},"page":"948-956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>Coronavirus disease 2019<\/scp> and pityriasis rosea: A review of the immunological connection"],"prefix":"10.1111","volume":"49","author":[{"given":"Francesco","family":"Borgia","sequence":"first","affiliation":[{"name":"Section Of Dermatology, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Li Pomi","sequence":"additional","affiliation":[{"name":"Section Of Dermatology, Department of Clinical and Experimental Medicine University of Messina  Messina 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