{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:28:42Z","timestamp":1781760522785,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with an increased prevalence of subclinical atherosclerosis and cardiovascular risk. Angiopoietin\u20102 (Ang\u20102), asymmetric dimethylarginine (ADMA), and osteoprotegerin (OPG) are molecules related to endothelial dysfunction (ED) and atherosclerosis, but also to disease severity in patients with chronic inflammatory disorders. In this case\u2013control study, we aimed to investigate serum Ang\u20102, ADMA, and OPG levels in patients with HS, and to assess the potential relationship between these levels and disease severity. Seventy\u2010five patients with HS and 60 controls were assessed. Serum Ang\u20102, ADMA, and OPG concentrations were determined in all participants. HS patients had significantly higher Ang\u20102 and ADMA levels than controls after adjusting for confounders. Besides, Ang\u20102 concentrations positively correlated with disease severity in the adjusted multivariable analysis. Nevertheless, serum OPG levels did not significantly differ between HS patients and controls. Our results indicate that serum Ang\u20102 and ADMA levels are significantly increased in patients with HS. Furthermore, Ang\u20102 might be a suitable marker of HS severity.<\/jats:p>","DOI":"10.1111\/1346-8138.16484","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T05:54:56Z","timestamp":1654494896000},"page":"1052-1056","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Biomarkers of endothelial dysfunction and atherosclerosis in hidradenitis suppurativa"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-5800","authenticated-orcid":false,"given":"Marcos A.","family":"Gonz\u00e1lez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Division of Dermatology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Gonzalo","family":"Ocejo\u2010Vi\u00f1als","sequence":"additional","affiliation":[{"name":"Division of Immunology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana E.","family":"L\u00f3pez\u2010Sundh","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Guiral","sequence":"additional","affiliation":[{"name":"Division of Immunology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ruiz\u2010Solana","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mata","sequence":"additional","affiliation":[{"name":"Division of Rheumatology Hospital Comarcal  Laredo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Portilla","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Corrales","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Blanco","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6585-8847","authenticated-orcid":false,"given":"Jose L.","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, Hospital Universitario Marqu\u00e9s de Valdecilla University of Cantabria, IDIVAL  Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431175"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.10.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3412"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.025"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6813016"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12726"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.09.019"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13094"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15748"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106223"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13529"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14620"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3897295"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-20993"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.09.025"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16484","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:47:32Z","timestamp":1758721652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/1346-8138.16484"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16484","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]},"assertion":[{"value":"2022-03-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}