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Here, we report the relevance of the ectopic expression of keratan sulfate (KS) glycan chains in human malignant melanomas. Using a human melanoma cell line, we found that the KS enhanced the invasiveness of the cells but caused no change in the growth rate of the cells. The phosphorylation of paxillin, a focal adhesion\u2010associated adaptor protein, was strong at the region where KS was expressed in the melanoma tissues, indicating that KS stimulated the phosphorylation of paxillin. We also observed that KS enhanced the adhesion of melanoma cells and this was accompanied by a greatly increased level of phosphorylation of paxillin. These data suggest that the expression of KS contributes to the development of malignant phenotypes such as strong cell adhesion and the invasiveness of melanoma cells.<\/jats:p>","DOI":"10.1111\/1346-8138.16506","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:50:15Z","timestamp":1657500615000},"page":"1027-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The expression of keratan sulfate in malignant melanoma enhances the adhesion and invasion activity of melanoma cells"],"prefix":"10.1111","volume":"49","author":[{"given":"Kota","family":"Tachibana","sequence":"first","affiliation":[{"name":"Department of Dermatologic Oncology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Dermatology, Dentistry and Pharmaceutical Science Okayama University Graduate School of Medicine  Okayama 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