{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:44:05Z","timestamp":1777034645145,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004095","name":"Kyowa Kirin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis poses a substantial economic burden by reducing the work productivity of affected patients. We aimed to evaluate the negative impact of plaque psoriasis on work productivity and effectiveness of brodalumab in improving work productivity impairment in real\u2010life employed patients. This analysis was conducted in employed patients from ProLOGUE, an open\u2010label, multicenter, prospective cohort study (Japan Registry of Clinical Trials identifier: jRCTs031180037). Outcomes included association of Work Productivity and Activity Impairment\u2010Psoriasis (WPAI\u2010PSO) domain scores with scores from various patient\u2010reported outcome measures or Psoriasis Area and Severity Index (PASI) scores at baseline. Change from baseline in WPAI\u2010PSO domain scores following brodalumab treatment was also evaluated. Of the 73 patients enrolled, 51, 48, and 40 patients were considered employed at baseline, Week 12, and Week 48 of brodalumab treatment, respectively. In the model adjusted by age and sex, the work productivity loss score correlated with the Dermatology Life Quality Index (DLQI), itch Numeric Rating Scale (NRS), Patient Health Questionnaire\u20108 (PHQ\u20108), and skin pain NRS scores (partial Spearman correlation coefficient [<jats:italic>\u03c1<\/jats:italic>]\u00a0=\u00a00.608, 0.510, 0.461, and 0.424, respectively); presenteeism score correlated with the DLQI, itch NRS, and skin pain NRS scores (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.568, 0.500, and 0.403, respectively); and activity impairment score correlated with the DLQI and PHQ\u20108 scores (<jats:italic>\u03c1<\/jats:italic>\u00a0=\u00a00.530 and 0.414, respectively). None of the WPAI\u2010PSO domain scores correlated with the PASI score. All WPAI\u2010PSO domain scores (except absenteeism) significantly reduced from baseline to Weeks 12 (<jats:italic>p<\/jats:italic>\u2009&lt; 0.0001) and 48 (<jats:italic>p<\/jats:italic>\u2009&lt; 0.001) with brodalumab treatment. In conclusion, work productivity impairment in psoriasis was associated with various subjective symptoms that can be captured using patient\u2010reported outcome measures. Brodalumab treatment improved work productivity in real\u2010life employed patients with plaque psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.16517","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T05:25:56Z","timestamp":1658294756000},"page":"970-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Work productivity in real\u2010life employed patients with plaque psoriasis: Results from the <scp>ProLOGUE<\/scp> study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0355","authenticated-orcid":false,"given":"Hidehisa","family":"Saeki","sequence":"first","affiliation":[{"name":"Department of Dermatology Nippon Medical School  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasumasa","family":"Kanai","sequence":"additional","affiliation":[{"name":"Medical Affairs Kyowa Kirin Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Murotani","sequence":"additional","affiliation":[{"name":"Biostatistics Center Kurume University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kei","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Dermatology JR Sapporo Hospital  Sapporo\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Miyagi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of the Ryukyus  Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5375-3266","authenticated-orcid":false,"given":"Hidetoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Takagi Dermatological Clinic  Obihiro\u2010shi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3743-135X","authenticated-orcid":false,"given":"Yayoi","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Higashiyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Life Hospital  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8070-9751","authenticated-orcid":false,"given":"Yuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toho University School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kitabayashi","sequence":"additional","affiliation":[{"name":"Medical Affairs Kyowa Kirin Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8568-4349","authenticated-orcid":false,"given":"Shinichi","family":"Imafuku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fukuoka University Faculty of Medicine  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14864"},{"key":"e_1_2_8_3_1","article-title":"Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database","volume":"5","author":"Kubota K","year":"2015","journal-title":"BMJ"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70112-X"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.05.012"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18798"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13439"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13859"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14876"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.10.020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.0269"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15094"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109017"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2015.10.009"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0634-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-019-00334-1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13248"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14870"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-199304050-00006"},{"key":"e_1_2_8_20_1","unstructured":"Margaret Reilly Associates Inc.Work productivity and activity impairment questionnaire: Psoriasis (WPAI:PSO) [Internet]. [cited 2022 March 9].http:\/\/www.reillyassociates.net\/WPAI\u2010PSORIASIS\u2010English\u2010US_.doc"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15098"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.01.002"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2022.02.007"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12645"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.034"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1456"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-36"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2008.06.026"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2008.06.003"},{"key":"e_1_2_8_32_1","first-page":"47","article-title":"Developing a Japanese version of the EQ\u20105D\u20105L value set","volume":"64","author":"Ikeda S","year":"2015","journal-title":"J Natl Inst Public Health"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-019-0634-5"},{"key":"e_1_2_8_34_1","unstructured":"National Tax Agency Commissioner's Secretariat Planning Division.2017 statistics on average wage in private companies (in Japanese) [internet]. [cited 2022 March 9].https:\/\/www.nta.go.jp\/publication\/statistics\/kokuzeicho\/minkan2017\/pdf\/000.pdf"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2009.08068"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500482886"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.043"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1628172"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2020.1750552"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0866-y"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.2165\/11530640-000000000-00000"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.06.003"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2018.24.7.617"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000093848"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.08.008"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16517","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16517","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:48:25Z","timestamp":1758721705000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,20]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/1346-8138.16517"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16517","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,20]]},"assertion":[{"value":"2022-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}