{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T05:11:27Z","timestamp":1777871487300,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008271","name":"LEO Pharma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An innovative foam formulation for the fixed\u2010dose combination of calcipotriol and betamethasone dipropionate (Cal\/BD) has recently become available for the treatment of psoriasis vulgaris. Observational studies of patients treated with Cal\/BD foam in routine practice have been conducted in several Western countries, but there are limited data on outcomes in Asian patients. We performed a prospective, open\u2010label, noncomparative, noninterventional study to investigate treatment outcomes and satisfaction in adult patients receiving Cal\/BD foam for psoriasis vulgaris in dermatological centers and outpatient clinics in Korea. Data were collected at the time of enrollment (Visit 1) and at a routine clinic visit ~4\u2009weeks later (Visit 2). In total, 218 patients were enrolled, of whom 175 were included in the safety analysis set (58.9% male; mean age\u2009\u00b1\u2009standard deviation 46.7\u00a0\u00b1\u200915.1\u2009years; use of Cal\/BD foam at least once daily 74.3%). Of the safety analysis set, 166 patients had at least mild psoriasis (Investigator Global Assessment [IGA]\u2009\u2265\u20092) and were analyzed for treatment outcomes and satisfaction. Of the 166 patients, 71.7% had mild psoriasis (IGA 2) at baseline. The majority (57.8%) achieved an IGA of 0\/1 (clear\/almost clear) at Visit 2. The Psoriasis Area Severity Index (PASI) and Dermatology Life Quality Index (DLQI) showed significant improvements from Visit 1 to Visit 2 (PASI \u22122.4\u00a0\u00b1\u20093.0, DLQI \u22124.5\u00a0\u00b1\u20095.2, both <jats:italic>P<\/jats:italic>\u00a0&lt;\u20090.0001). Most of the patients were satisfied with the Cal\/BD foam treatment; 77.0%, 60.0%, and 73.9% were satisfied in terms of effectiveness, ease of use, and global satisfaction, respectively. In the safety analysis set, adverse events were reported in 13 patients (7.4%). In conclusion, this first Korean real\u2010world study of Cal\/BD foam shows improvement of lesions and health\u2010related quality of life after 4\u2009weeks of treatment, with high global satisfaction and good overall tolerability and safety.<\/jats:p>","DOI":"10.1111\/1346-8138.16519","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T07:48:34Z","timestamp":1658130514000},"page":"1085-1095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Calcipotriol\/betamethasone aerosol foam (Enstilum) for the topical treatment of psoriasis vulgaris in routine practice in Korea: A prospective, noninterventional, multicenter study of treatment outcomes and patient satisfaction"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-7672","authenticated-orcid":false,"given":"Seong Jin","family":"Jo","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University College of Medicine and Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul\u2010Jong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bucheon St. Mary's Hospital The Catholic University of Korea  Bucheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6246-0331","authenticated-orcid":false,"given":"Chul Hwan","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul St. Mary's Hospital The Catholic University of Korea  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki\u2010Heon","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Dermatology KyungHee University Medical Center  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chosun University Hospital  Gwangju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Cha University Bundang Medical Center  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Jin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inje University Ilsan Paik Hospital  Goyang South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0054-8570","authenticated-orcid":false,"given":"Byung\u2010Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pusan National University Hospital  Busan South 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