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The aim of this study was to measure serum cfDNA levels in patients with cutaneous T\u2010cell lymphoma (CTCL) and to evaluate their correlations with hematological and clinical findings. Serum cfDNA levels in CTCL patients were significantly higher than those in healthy controls, and their levels gradually increased with the progression of the disease stage. Positive correlations were detected between serum cfDNA levels and those of lactate dehydrogenase, thymus and activation\u2010regulated chemokine and soluble IL\u20102 receptor as well as neutrophil and eosinophil count in peripheral blood and neutrophil\u2010to\u2010lymphocyte ratio. Furthermore, CTCL patients with higher serum cfDNA levels exhibited a significantly worse prognosis. Taken together, these results suggest the potential of cfDNA as a new biomarker reflecting prognosis and disease activity in CTCL. CfDNA levels may serve as an indicator for considering the intensity and timing of subsequent therapeutic intervention.<\/jats:p>","DOI":"10.1111\/1346-8138.16520","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T05:46:10Z","timestamp":1657691170000},"page":"1124-1130","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum cell\u2010free <scp>DNA<\/scp> as a new biomarker in cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"49","author":[{"given":"Yuka","family":"Mizuno","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3382-8026","authenticated-orcid":false,"given":"Sayaka","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate 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