{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:23:10Z","timestamp":1791894190473,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The real\u2010world treatment landscape for patients with moderate\u2010to\u2010severe psoriasis receiving systemic therapies in Japan is not well understood. This study describes the demographic and clinical characteristics, treatment patterns, healthcare resource utilization, and psoriasis\u2010associated costs in these patients. This retrospective observational study used data from the Japan Medical Data Center database between January 2016 and December 2020. Eligible patients had a confirmed diagnosis of psoriasis, \u22651 claim for a systemic treatment of interest, medical history for \u22656\u00a0months, and follow\u2010up data for \u226512\u2009months. Systemic therapies comprised biologics (tumor necrosis factor and interleukin inhibitors) and oral treatments (a phosphodiesterase\u20104 inhibitor, immunosuppressants, and vitamin A). Patient demographics and clinical characteristics, treatment patterns, healthcare resource utilization, and costs were evaluated. The study identified 1770 patients satisfying all inclusion criteria. The mean age was 49.0\u2009years, with 68% of patients aged 20\u201354\u2009years. Overall, 90.6% and 9.4% of patients received oral medications and biologics as index treatment, respectively. Treatment patterns, healthcare resource utilization, and costs were assessed for treatments received by \u226520 patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a01730). During the 12\u2010month follow\u2010up period, 1102\/1730 patients (63.7%) discontinued index treatment, of whom 9.9% switched to alternative systemic treatments. The persistence rate was \u226570% for most biologics and\u2009&lt;50% for oral systemic treatments. All 1730 patients had \u22651 all\u2010cause outpatient visit (2.0 visits per person per month) and hospitalization frequency was \u22640.01 per person per month. Persistent patients incurred inflation\u2010adjusted costs of Japanese Yen (JPY) 88\u2009667 per person per month. Treatment switching was associated with an increase in total cost: JPY 128\u2009039 per person per month after switching versus JPY 117\u2009504 before switching. This study of Japanese patients with moderate\u2010to\u2010severe psoriasis demonstrated low persistence, high discontinuation, and low rates of treatment switching with systemic therapies. Switching was associated with increased total cost. These results indicate unmet needs for new treatments.<\/jats:p>","DOI":"10.1111\/1346-8138.16543","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T08:02:35Z","timestamp":1660118555000},"page":"1106-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Treatment patterns, healthcare resource utilization, and costs in patients with moderate\u2010to\u2010severe psoriasis treated with systemic therapy in Japan: A retrospective claims database study"],"prefix":"10.1111","volume":"49","author":[{"given":"Yayoi","family":"Tada","sequence":"first","affiliation":[{"name":"Teikyo University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2149-2345","authenticated-orcid":false,"given":"Hyunchung","family":"Kim","sequence":"additional","affiliation":[{"name":"Bristol Myers Squibb  Tokyo 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