{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:40:18Z","timestamp":1779248418983,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicle that has previously been associated with a higher cardiovascular risk (CVR). Although different methods have been described for CVR stratification in HS, there is little evidence about the role of hemogram indexes in CVR in HS. Given its potential convenience, the aim of this study was to assess the role of the hemogram indexes systemic immune\u2010inflammation index (SII) and neutrophil\u2010lymphocyte ratio (NLR) in CVR stratification for patients with HS. A cross\u2010sectional study was performed to assess the role of SII and NLR in CVR stratification in patients with moderate to severe HS who were candidates for biologic therapy. SII, NLR, carotid intima\u2010media thickness, and other clinical and biochemical CVR factors were assessed before the start of the treatment. Fifty patients were included. The male:female ratio was 3:2, and the mean International Hidradenitis Suppurativa Severity Score System score was 21.6. After multivariate analysis, SII correlated with higher values of systolic blood pressure, metabolic syndrome, and higher risk of insulin resistance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). NLR was associated with insulin resistance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). These associations were independent of age, sex, body mass index, severity of the disease, and tobacco consumption. The implementation of SII and NLR in daily practice may be of benefit for identifying patients with HS at higher risk of high blood pressure, insulin resistance, or metabolic syndrome. Since these indexes are simple to calculate, they could be used as a screening tool in HS\u2010specific units.<\/jats:p>","DOI":"10.1111\/1346-8138.16558","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T07:34:44Z","timestamp":1661326484000},"page":"1238-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exploring the role of systemic immune\u2010inflammation index and neutrophil\u2010lymphocyte ratio in cardiovascular risk stratification for patients with hidradenitis suppurativa: A cross\u2010sectional study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-1558","authenticated-orcid":false,"given":"Manuel","family":"S\u00e1nchez\u2010D\u00edaz","sequence":"first","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves IBS Granada  Granada 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Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Molina\u2010Leyva","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves IBS Granada  Granada Spain"},{"name":"Hidradenitis Suppurativa Clinic Hospital Universitario Virgen de las Nieves  Granada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513044"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15038"},{"key":"e_1_2_7_4_1","first-page":"242","article-title":"Cardiovascular risk in psoriasis patients: clinical, functional and morphological parameters","volume":"113","author":"Oliveira AN","year":"2019","journal-title":"Arq Bras 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