{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T01:36:38Z","timestamp":1772242598918,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T00:00:00Z","timestamp":1663977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002429","name":"Amgen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002429","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Phototherapy and apremilast (oral phosphodiesterase\u20104 inhibitor) are well\u2010known in the treatment of moderate to severe psoriasis vulgaris. However, current evidence on the efficacy and safety of their combination is not sufficient. This multicenter, randomized controlled study compared the efficacy and safety between phototherapy as monotherapy and phototherapy and apremilast as combination therapy in patients with psoriasis vulgaris. Patients with moderate to severe psoriasis vulgaris were assigned to combination (<jats:italic>n<\/jats:italic>\u00a0=\u00a029) and monotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) groups. All patients underwent an 8\u2010week phototherapy regimen comprising irradiation with narrowband UV\u2010B. The patients in the combination group were also administered 10 mg to 60\u2009mg of oral apremilast. We evaluated the improvement percentage based on the Psoriasis Area and Severity Index (PASI) score from baseline to week 8. Additionally, we evaluated the percentage of patients who achieved \u226575% improvement; changes in body surface area (BSA) and scores of EuroQol 5\u2010dimensions 5\u2010level, Dermatology Life Quality Index, and visual analog scale for pruritis from baseline to 4 and 8\u2009weeks; and adverse events. Compared with the monotherapy group, the combination group had significantly lower PASI scores at 4 and 8\u2009weeks and more patients who achieved a PASI score improvement of \u226575% at 8\u2009weeks. Both groups exhibited a significant decrease in BSA; at 8\u2009weeks, no significant difference was observed between the two groups, although the combination group tended toward a greater reduction in BSA. The intergroup differences in the changes at the three time points were not significant. Adverse events were more frequent in the combination group than in the monotherapy group. Our findings suggest that an 8\u2010week combined apremilast and phototherapy regimen may not be adequate in patients for improvements in their subjective assessment of psoriasis, and longer treatment periods may be necessary.<\/jats:p>","DOI":"10.1111\/1346-8138.16566","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T07:58:35Z","timestamp":1664006315000},"page":"1211-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy and safety of apremilast and phototherapy versus phototherapy only in psoriasis vulgaris"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8372-3754","authenticated-orcid":false,"given":"Akimichi","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-6627","authenticated-orcid":false,"given":"Yukie","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka Metropolitan University, Graduate School of Medicine  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Ikumi","sequence":"additional","affiliation":[{"name":"Department of Geriatric and Environmental Dermatology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department 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