{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:13:03Z","timestamp":1755796383027,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>CD134\/OX40, a member of the tumor necrosis factor receptor superfamily, is a cell\u2010specific receptor for human herpesvirus 6 (HHV\u20106) variant B. Patients with drug\u2010induced hypersensitivity syndrome (DIHS)\/drug reaction with eosinophilia and systemic symptoms (DRESS) present a significant increase in CD134 expression in peripheral blood CD4<jats:sup>+<\/jats:sup> T cells. We aimed to investigate the frequency of CD134<jats:sup>+<\/jats:sup> CD4 T cells infiltrating skin lesions in patients with DIHS\/DRESS and its association with disease severity. We retrospectively included 21 patients with DIHS\/DRESS and 11 patients with erythema multiforme (EM). By immunohistochemistry, the frequency of CD134<jats:sup>+<\/jats:sup> CD4 T cells in DIHS was significantly higher than that in EM (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0083). The DIHS\/DRESS severity score was significantly correlated with the frequency of CD134<jats:sup>+<\/jats:sup> CD4 T cells (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0272); moreover, there was a significant difference between severe and mild\/moderate cases. Double immunofluorescence staining revealed that numerous cells presented CD134\/CD4 and CD134\/Foxp3 overlap in patients with DIHS\/DRESS. These data suggest increased susceptibility to HHV\u20106 infection at localized skin sites. HHV\u20106 may be involved in the mechanism underlying the progression and pathophysiology of DIHS\/DRESS.<\/jats:p>","DOI":"10.1111\/1346-8138.16575","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T11:30:53Z","timestamp":1663587053000},"page":"387-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased expression of human herpes virus 6 receptor <scp>CD134<\/scp>\/<scp>OX40<\/scp> in skin lesions of patients with drug\u2010induced hypersensitivity syndrome\/drug reaction with eosinophilia and systemic symptoms"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-0960","authenticated-orcid":false,"given":"Eun Seon","family":"Lee","sequence":"first","affiliation":[{"name":"Departments of Dermatology Showa University School of Medicine  Shinagawa\u2010ku Tokyo Japan"},{"name":"Departments of Pharmacology Showa University School of 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