{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:26:09Z","timestamp":1789961169972,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is characterized by increased dermal vascularity, indicating that aberrant angiogenesis is associated with the pathogenesis of psoriasis. Data on angiogenesis\u2010related factors in psoriasis patients are limited. We explored serum levels of angiogenesis\u2010related factors in patients with psoriasis, and investigated their association with clinical severity and laboratory data. Psoriasis patients visiting our hospital from April 2013 to April 2018 and healthy controls were included in this study. Serum levels of angiopoietin\u20101, fibroblast growth factor (FGF)\u2010basic, epidermal growth factor (EGF), platelet endothelial cell adhesion molecule (PECAM)\u20101, placental growth factor, and vascular endothelial growth factor (VEGF) were measured by LEGENDplex. Serum samples obtained from 10 healthy controls, 18 patients with psoriasis vulgaris (PsV), 24 patients with psoriatic arthritis (PsA), and 13 patients with generalized pustular psoriasis (GPP) were analyzed. The serum angiopoietin\u20101 level was elevated in the PsV, PsA, and GPP patients. GPP patients had a higher serum VEGF level than healthy controls. In contrast, serum levels of EGF and PECAM\u20101 were lower in the PsV, PsA, and GPP patients than in healthy controls. The serum FGF\u2010basic level was lower in the PsA and GPP patients than in healthy controls. Serum levels of FGF\u2010basic in PsA and GPP patients, PECAM\u20101 in PsA patients, and VEGF in GPP patients became closer to the respective levels in healthy controls after systemic therapy. The serum FGF\u2010basic level was positively correlated with the psoriasis area and severity index and the number of circulating eosinophils in GPP patients. The serum VEGF level was correlated positively with the serum C\u2010reactive protein (CRP) level and erythrocyte sedimentation rate, and negatively with the serum albumin level in GPP patients. In conclusion, our exploratory study revealed that psoriasis affects serum levels of certain angiogenesis\u2010related factors. Some of these factors could be biomarkers of treatment outcomes, clinical severity, and systemic inflammation.<\/jats:p>","DOI":"10.1111\/1346-8138.16588","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T07:44:31Z","timestamp":1663573471000},"page":"222-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Serum levels of angiogenesis\u2010related factors in patients with psoriasis"],"prefix":"10.1111","volume":"50","author":[{"given":"Ayu","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0976-4982","authenticated-orcid":false,"given":"Masahiro","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Tokyo 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