{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:51Z","timestamp":1787013591921,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Whether sentinel lymph node biopsy status is a prognostic factor or effective in determining treatment strategies in extramammary Paget disease remains unclear. This study aimed to investigate the significance of sentinel lymph node biopsy in extramammary Paget disease. We retrospectively reviewed the clinical information of previously untreated patients with invasive extramammary Paget disease who underwent wide local excision of the primary tumor and sentinel lymph node biopsy at our hospital between April 2008 and March 2021. Clinical data including the baseline neutrophil\u2010to\u2010lymphocyte ratio and recurrence\u2010free survival were analyzed. Sentinel lymph node metastases were classified as macrometastases and micrometastases, with a cut\u2010off value for sentinel lymph node tumor burden of 2\u2009mm. Univariate and multivariate analyses of factors affecting sentinel lymph node biopsy positivity and recurrence\u2010free survival rates were performed. Overall, 85 patients were included in the analysis. Patients in the sentinel lymph node biopsy\u2010positive group (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a026) had a significantly higher invasion level and neutrophil\u2010to\u2010lymphocyte ratio. According to multivariate analyses, invasion level and a high neutrophil\u2010to\u2010lymphocyte ratio were independent predictive factors for sentinel lymph node biopsy positivity, and the sentinel lymph node biopsy status was an independent prognostic factor for recurrence\u2010free survival. In conclusion, sentinel lymph node biopsy provides an accurate risk classification and clinical indication for postoperative follow\u2010up in patients with invasive extramammary Paget disease.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.16602","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T03:30:20Z","timestamp":1665459020000},"page":"57-63","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sentinel lymph node biopsy in extramammary Paget disease: A 13\u2010year institutional experience"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9332-4773","authenticated-orcid":false,"given":"Takuya","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Dermatologic Oncology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo 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