{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:50Z","timestamp":1747181990998,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most common treatment option for patients with bullous pemphigoid is systemic corticosteroids. CYP3A4, a drug\u2010metabolizing enzyme in the liver, metabolizes synthetic steroids to a varying degree. Although there are many CYP3A4\u2010inducing drugs, several antiepileptic drugs, such as phenytoin and phenobarbital, strongly induce CYP3A4, thereby reducing the effects of corticosteroids. Here, we report a case of refractory bullous pemphigoid that rapidly improved after the discontinuation of phenytoin and phenobarbital. To achieve adequate pharmacological effects of corticosteroids, we must always ensure that patients who require corticosteroids for treatment are not medicated with CYP3A4\u2010inducing agents.<\/jats:p>","DOI":"10.1111\/1346-8138.16624","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T09:27:21Z","timestamp":1667294841000},"page":"254-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Case of bullous pemphigoid refractory to corticosteroids by antiepileptic drug\u2010induced <scp>CYP3A4<\/scp>"],"prefix":"10.1111","volume":"50","author":[{"given":"Riko","family":"Asakawa","sequence":"first","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-888X","authenticated-orcid":false,"given":"Youichi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Honobe\u2010Tabuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1228-603X","authenticated-orcid":false,"given":"Takashi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1167-3038","authenticated-orcid":false,"given":"Hiroshi","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Pharmaceutics, School of Pharmaceutical Sciences University of Shizuoka  Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyoshi","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/j.jdermsci.2021.11.003"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1111\/1346-8138.15111"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/0003-9861(88)90655-8"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1097\/FTD.0000000000000518"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.2340\/00015555-3472"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1111\/j.1365-2125.2010.03773.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1016\/0960-0760(93)90013-M"},{"doi-asserted-by":"publisher","key":"e_1_2_6_9_1","DOI":"10.1172\/JCI3703"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.2165\/00003088-200847100-00004"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1007\/s40262-017-0523-7"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1007\/s40262-018-0703-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1007\/s00280-011-1772-z"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1002\/cpdd.578"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1038\/clpt.1987.173"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1507\/endocrine1927.61.3_145"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16624","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.16624","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16624","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T12:12:09Z","timestamp":1692274329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16624"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/1346-8138.16624"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16624","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"2022-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}