{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:52:38Z","timestamp":1782125558178,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Holocarboxylase synthetase deficiency (HSD) is a rare autosomal recessive disorder of biotin metabolism. Typical manifestations include irreversible metabolic disorders and erythroderma\u2010like dermatitis. Most patients respond well to biotin supplementation. Psoriasis\u2010like phenotype associated with this disease has been rarely reported in the literature and experiences with the use of biologics in patients with HSD are still lacking. We reported a rare case of recurrent psoriasis\u2010like skin lesions in a 6\u2010year\u2010old child with HSD. The patient did not respond to initial therapy with high\u2010dose oral biotin. Immunofluorescence staining\u00a0showed an increased number of interleukin (IL)\u201017A+ cells in his skin lesions. Based on this finding, the patient was successfully treated with human anti\u2010IL\u201017A monoclonal antibody (secukinumab). He did not report any side effects and remained healthy during the 2\u2010year follow\u2010up. We provide a comprehensive review of the reported cases of HSD with psoriasis\u2010like dermatitis to date. The psoriasis\u2010like phenotype of HSD is controversial in treatment and IL\u201017A inhibitor is an alternative therapeutic option.<\/jats:p>","DOI":"10.1111\/1346-8138.16625","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T12:05:49Z","timestamp":1667822749000},"page":"401-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful treatment with secukinumab of psoriasis\u2010like dermatitis in a patient with holocarboxylase synthetase deficiency"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-5899","authenticated-orcid":false,"given":"Haifei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Institute of Dermatology, School of Medicine Shanghai Jiao Tong University  Shanghai 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