{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:23:37Z","timestamp":1787783017992,"version":"build-2784847793"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is a common depigmenting skin disease that is often difficult to treat. Even if repigmentation is achieved by treatment, recurrence in the same lesion is often found within a year after stopping treatment. As a background of these issues, a subset of CD8<jats:sup>+<\/jats:sup> T cells that recognize melanocyte\u2010specific antigens or CD49a<jats:sup>+<\/jats:sup> tissue\u2010resident memory T cells that reside in the vitiligo lesion are thought to be involved. We investigated the MHC class I\u2010restricted tyrosinase pentamer\u2010positive CD8<jats:sup>+<\/jats:sup> skin T cells in a progressive generalized vitiligo patient with HLA\u2010A*02:01 who showed resistance to intravenous methylprednisolone pulse therapy. We found that HLA\u2010A*02:01\u2010restricted tyrosinase pentamer\u2010positive CD8<jats:sup>+<\/jats:sup> T cells remained in the lesions after the treatment and expressed IFN\u2010\u03b3 and granzyme B. Interestingly, the expression of these cytokines in the pentamer\u2010negative CD8<jats:sup>+<\/jats:sup> T cells was decreased after intravenous methylprednisolone pulse therapy. These findings suggest that, in vitiligo patients, melanocyte\u2010specific CD49a<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> T cells are in a potent activation state that is uncontrolled despite systemic immunosuppressive treatment, which may contribute to treatment resistance and local recurrence.<\/jats:p>","DOI":"10.1111\/1346-8138.16680","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T08:21:30Z","timestamp":1671006090000},"page":"710-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Melanocyte\u2010specific <scp>CD49a<\/scp><sup>+<\/sup><scp>CD8<\/scp><sup>+<\/sup> T cells in vitiligo lesion potentiate to maintain activity during systemic steroid therapy"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0582-7325","authenticated-orcid":false,"given":"Kazunori","family":"Yokoi","sequence":"first","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Kume","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Experimental Immunology, Immunology Frontier Research Center, Faculty of Medicine Osaka University  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5239-8474","authenticated-orcid":false,"given":"Atsushi","family":"Tanemura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Osaka 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