{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T21:04:32Z","timestamp":1767474272629,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009158","name":"Kawasaki Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009158","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20ek0410068h0001"],"award-info":[{"award-number":["20ek0410068h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bullous systemic lupus erythematosus (BSLE) is a rare blistering disease in patients with SLE. BSLE is a heterogenous disease caused by autoantibodies to the basement membrane, mainly type VII collagen. The pathogenesis of the development of autoantibodies in BSLE remains unknown. We report a case of SLE taking dipeptidyl peptidase 4 inhibitors (DPP4i) who developed tense blister lesions after administration of SARS\u2010CoV\u20102 vaccine. Initial erythematous lesion before administration of SARS\u2010CoV\u20102 vaccine had not shown IgG deposition at basement membrane both direct and indirect immunofluorescence (IIF). However, the result of those examinations became positive after the administration of SARS\u2010CoV\u20102 vaccine. Furthermore, IIF test results using NaCl split skin had shown positive against epidermal side. These observations suggest that SARS\u2010CoV\u20102 vaccination triggered production of autoantibodies that cause bullous SLE. The present case fulfills the diagnostic criteria for both BSLE and DPP4i\u2010associated bullous pemphigoid. Skin lesions were cleared after withdrawal of DPP4i. Therefore, physicians should ask patients who develop blisters after the vaccination whether they are taking DPP4i.<\/jats:p>","DOI":"10.1111\/1346-8138.16687","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T05:21:17Z","timestamp":1672291277000},"page":"162-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>SARS\u2010CoV<\/scp>\u20102 vaccine\u2010triggered conversion from systemic lupus erythematosus (<scp>SLE<\/scp>) to bullous <scp>SLE<\/scp> and dipeptidyl peptidase 4 inhibitors\u2010associated bullous pemphigoid"],"prefix":"10.1111","volume":"50","author":[{"given":"Yukiko","family":"Nakahara","sequence":"first","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6840-2442","authenticated-orcid":false,"given":"Mariko","family":"Yamane","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Sunada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3701-5575","authenticated-orcid":false,"given":"Yumi","family":"Aoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kawasaki Medical School  Okayama 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