{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:58Z","timestamp":1747181998331,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous lichen planus is a highly pruritic dermatosis with an unmet need in its management. The aim of this study was to evaluate the short\u2010term effect and tolerance of high doses of clobetasol propionate 0.05% in cutaneous lichen planus. We conducted a single\u2010center retrospective cohort study from 2017 to 2021. All adults treated with high\u2010dose (&gt;5\u00a0g\/day) clobetasol propionate 0.05% for cutaneous lichen planus were included. Patients with less than 10% affected body surface area at initial presentation or who received concomitant systemic therapy were excluded. The primary endpoint was the rate of complete remission by week 16. Secondary endpoints included maximum daily and median cumulative doses, reduction in pruritus and occurrence of adverse events. Fifty\u2010seven patients, 60% female, with a mean age of 48\u2009years (min\u2013max,18\u201383) were included. Cutaneous lichen planus had been present for a median duration of 2\u00a0months at initial presentation (min\u2013max, 1\u20134) and involved a median body surface area of 27%. Pruritus was reported by 55\/57 (96%) patients. At week 16, 41\/57 (72%) patients had achieved complete remission without treatment modification, among whom 25\/41 (61%) had achieved it at week 6. The median daily and cumulative doses were, respectively, 20\u2009g\/day (IQR, 10\u201320) and 560\u2009g (IQR, 320\u2013925). Three patients experienced mild adverse events. No statistical association was demonstrated between the duration of the disease before treatment initiation and clinical response. In conclusion, high\u2010dose clobetasol propionate 0.05% seems to be an effective, well\u2010tolerated, and easy\u2010to\u2010implement treatment for cutaneous lichen planus.<\/jats:p>","DOI":"10.1111\/1346-8138.16689","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T04:55:02Z","timestamp":1672289702000},"page":"810-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Safety and efficacy of high\u2010dose clobetasol propionate 0.05% in cutaneous lichen planus"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1419-8180","authenticated-orcid":false,"given":"Audrey","family":"Melin","sequence":"first","affiliation":[{"name":"Department of Dermatology, AP\u2010HP, H\u00f4pital Henri Mondor, Facult\u00e9 de Sant\u00e9 Universit\u00e9 Paris\u2010Est  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bouchereau","sequence":"additional","affiliation":[{"name":"Department of Dermatology, AP\u2010HP, H\u00f4pital Henri Mondor, Facult\u00e9 de Sant\u00e9 Universit\u00e9 Paris\u2010Est  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Guelimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, AP\u2010HP, H\u00f4pital Henri Mondor, Facult\u00e9 de Sant\u00e9 Universit\u00e9 Paris\u2010Est  Cr\u00e9teil France"},{"name":"EpiDermE Epidemiology in Dermatology and Evaluation of Therapeutics, EA7379 Paris ESt Cr\u00e9teil University UPEC  Cr\u00e9teil France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"Bergqvist","sequence":"additional","affiliation":[{"name":"Department of Dermatology, AP\u2010HP, H\u00f4pital Henri Mondor, Facult\u00e9 de Sant\u00e9 Universit\u00e9 Paris\u2010Est  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