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Recently, IL\u201017\u2010mediated changes in the oral mycobiome, including the proliferation of <jats:italic>Candida<\/jats:italic> and <jats:italic>Aspergillus<\/jats:italic> fungi, have been proposed as a possible pathomechanism of oral lichen planus (OLP). We treated a 54\u2010year\u2010old male who had been suffering from psoriatic arthritis. Secukinumab rapidly improved the skin and joint symptoms, but a painful erosion on the lip and thrush on the buccal mucosa appeared within 4\u2009weeks. The erosion was histopathologically diagnosed as OLP. Although the candidiasis was successfully treated with topical miconazole nitrate, the labial OLP worsened during the secukinumab administration, despite the application of various topical agents. We finally switched from secukinumab to risankizumab, an anti\u2010IL\u201023p19 agent, which dramatically improved the patient's OLP lesion in 4\u2009weeks without candidiasis recurrence. Anti\u2010IL\u201023p19 agents do not affect the oral mycobiome, and they are a potential therapeutic option for refractory OLP, including OLP induced by biologics.<\/jats:p>","DOI":"10.1111\/1346-8138.16719","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T08:17:16Z","timestamp":1673425036000},"page":"824-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Secukinumab\u2010induced oral lichen planus in a psoriatic arthritis patient ameliorated after a switch to risankizumab"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-9261","authenticated-orcid":false,"given":"Yasuyuki","family":"Fujita","sequence":"first","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2522-7661","authenticated-orcid":false,"given":"Tatsuro","family":"Sugai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5649-8499","authenticated-orcid":false,"given":"Yuka","family":"Maya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2190-2877","authenticated-orcid":false,"given":"Emi","family":"Inamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Hirano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sapporo City General Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1007\/s10620-015-3680-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1111\/1346-8138.13637"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1016\/j.jdcr.2018.04.015"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.3389\/fimmu.2019.01808"},{"key":"e_1_2_6_6_1","article-title":"Clinical challenges and images in GI. 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