{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:29:59Z","timestamp":1790659799854,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T00:00:00Z","timestamp":1676851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010acne erythema (PAE) is one of the most common sequelae of acne inflammation. Unfortunately, the treatment of PAE remains challenging due to limited effective topical treatments. The objectives of this study were to evaluate the efficacy and safety of topical oxymetazoline hydrochloride (OxH) 0.05% solution for PAE. This study was a split\u2010face, participants\u2010and investigators\u2010blinded, randomized, placebo\u2010controlled trial conducted between December 2021 and March 2022 in Bangkok, Thailand. Healthy adults aged from 18 to 45\u2009years with mild to severe PAE, according to the Clinician's Erythema Assessment (CEA), on both sides of the face were eligible. After randomization, each participant applied the OxH to one side of their face and a placebo to the contralateral face twice daily for 12\u2009weeks. The primary outcome was PAE lesion counts. The secondary outcomes were erythema index, clinical response rate at week 12 (\u201cclear,\u201d \u201calmost clear,\u201d or \u201cat least two\u2010grade improvement\u201d by CEA), and patient satisfaction scores. A total of 30 participants were enrolled. The OxH\u2010treated skin showed a significantly greater mean difference (MD) reduction in PAE lesion counts than the placebo after 8\u2009weeks of treatment (4.30, 95% confidence interval [CI] 1.42\u20137.18). Similarly, the MD reduction of the erythema index was higher in the OxH\u2010treated skin from the second week (11.82, 95% CI 8.48\u201315.15). Additionally, the OxH\u2010treated side also achieved a higher clinical response rate after 8\u2009weeks of treatment (40.00% vs. 6.67%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and rated higher satisfaction than those using the placebo at the end of the study (mean [standard deviation] satisfaction score 8.30 [0.18] vs 7.40 [0.18], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). There were no serious adverse events or flares of erythema during the study. In conclusion, our study demonstrated that the topical OxH 0.05% solution was effective, well\u2010tolerated, and safe for reducing PAE without a rebound effect. It could be a choice of PAE management. Trial Registration: Thai Clinical Trials Registry No. TCTR20211207004.<\/jats:p>","DOI":"10.1111\/1346-8138.16749","type":"journal-article","created":{"date-parts":[[2023,2,20]],"date-time":"2023-02-20T11:48:02Z","timestamp":1676893682000},"page":"739-745","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of the topical nasal decongestant oxymetazoline as a novel therapeutic option for post\u2010acne erythema: A split\u2010face, double\u2010blind, randomized, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3394-4759","authenticated-orcid":false,"given":"Chanudda","family":"Washrawirul","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaporn","family":"Puaratana\u2010arunkon","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuda","family":"Chongpison","sequence":"additional","affiliation":[{"name":"Biostatistics Excellence Center, Research Affairs, The Skin and Allergy Research Unit, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopadon","family":"Noppakun","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2628-0894","authenticated-orcid":false,"given":"Pravit","family":"Asawanonda","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-0523","authenticated-orcid":false,"given":"Chanat","family":"Kumtornrut","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14804"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14729"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.023"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701646164"},{"key":"e_1_2_10_7_1","first-page":"46","article-title":"Easy as PIE (Postinflammatory erythema)","volume":"6","author":"Bae\u2010Harboe YS","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22321"},{"key":"e_1_2_10_9_1","first-page":"84","article-title":"Post\u2010acne erythema successfully treated with 595\u2010nm picosecond\u2010domain neodymium: yttrium\u2010aluminum\u2010garnet laser","volume":"9","author":"Kim J\u2010H","year":"2020","journal-title":"Med Laser; 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