{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:11:43Z","timestamp":1778807503755,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We accumulated the demographic information and analyzed the prevalence of myositis\u2010specific antibodies (MSAs) in a large cohort across Japan as standard testing for MSAs becomes more widely available. This retrospective, observational, cohort study analyzed the records of individuals aged 0\u201399\u2009years who are tested for serum MSAs at SRL Incorporation from January 2014 to April 2020 across Japan. An enzyme\u2010linked immunosorbent assay testing was applied to determine the presence of anti\u2010aminoacyl tRNA synthetase (anti\u2010ARS), anti\u2010Mi\u20102, anti\u2010melanoma differentiation\u2010associated gene 5 (anti\u2010MDA5), or anti\u2010transcriptional intermediary factor 1\u2010\u03b3 (anti\u2010TIF1\u03b3) (Medical and Biological Laboratories). Anti\u2010TIF1\u03b3 antibody was detected more in male patients than female patients. In contrast, women were predominant in patients with other MSAs. More than half of the anti\u2010ARS or anti\u2010TIF1\u03b3 antibody\u2010positive patients were over 60\u2009years old, although anti\u2010MDA5 or anti\u2010Mi\u20102\u2010positive patients were mostly under &lt;60\u2009years old. Anti\u2010MDA5 antibody\u2010positive patients were mostly aged 40\u201359\u2009years, while other MSA groups were mostly 60\u201379\u2009years. Anti\u2010MDA5 antibody was detected most frequently in the age range of 0\u201329\u2009years. Anti\u2010TIF1\u03b3 antibody was the second most commonly detected autoantibody in the age range of 0\u201319\u2009years. Anti\u2010ARS antibody was the most frequently detected autoantibody after the age of 30\u2009years, and the frequency of anti\u2010ARS gradually increased at more advanced ages. The second and third most detected autoantibodies were anti\u2010MDA5 and anti\u2010TIF1\u03b3, respectively, in ages 30\u201379\u2009years. We performed a nationwide &gt;3\u2010year evaluation of MSA detection in a routine diagnostic setting. This paper provides clinical images concerning the relationship between four MSA types and the distribution of sex and age in a large population.<\/jats:p>","DOI":"10.1111\/1346-8138.16772","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T05:35:48Z","timestamp":1678340148000},"page":"1058-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age distribution and prevalence in different age groups of four myositis\u2010specific autoantibodies, including <scp>anti\u2010ARS<\/scp>, <scp>anti\u2010MDA5<\/scp>, <scp>anti\u2010Mi<\/scp>\u20102, and <scp>anti\u2010TIF1\u03b3<\/scp> antibodies"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-5691","authenticated-orcid":false,"given":"Ikuko","family":"Ueda\u2010Hayakawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6749-4266","authenticated-orcid":false,"given":"Kyoko","family":"Tonomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aya","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emi","family":"Kaneda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-3437","authenticated-orcid":false,"given":"Noriko","family":"Arase","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Graduate School of Medicine  Suita 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