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From the above findings, the efficacy and safety profiles of taxane\u2010switch (change paclitaxel to docetaxel or vise), eribulin methylate, and pazopanib regimens in second\u2010line chemotherapy were evaluated retrospectively in 50 Japanese taxane\u2010resistant CAS patients. Although there was no significant difference in progression\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.3528) among the regimens, the incidence of all adverse events (AEs) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0386), as well as severe G3 or more AEs (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0477) was significantly higher in the eribulin methylate group and pazopanib group than in the taxane\u2010switch group. The present data suggest that switching to another taxane should be considered for the treatment of taxane\u2010resistant CAS in second\u2010line therapy based on the safety profiles.<\/jats:p>","DOI":"10.1111\/1346-8138.16786","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T08:25:55Z","timestamp":1679300755000},"page":"912-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Treatment for taxane\u2010resistant cutaneous angiosarcoma: A multicenter study of 50 Japanese cases"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai 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