{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T13:36:18Z","timestamp":1785591378928,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["2021\u201032\u20100033"],"award-info":[{"award-number":["2021\u201032\u20100033"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Generalized bullous fixed drug eruption (GBFDE) is a rare type of life\u2010threatening severe cutaneous adverse reaction that is considered a medical emergency because of its potential lethality. Currently, only a few cases of bullous adverse reactions have been reported after coronavirus disease 2019 (COVID\u201019) vaccination. We describe a patient with distinct clinical, histopathological, and immunological findings that are consistent with severe GBFDE, after Pfizer messenger RNA COVID\u201019 vaccination. An 83\u2010year\u2010old man presented with a fever and well\u2010demarcated multiple erythematous patches that occurred only 4\u2009h after receiving the first dose of COVID\u201019 Pfizer vaccination. Over the next few days, the patches became generalized and turned into blisters covering approximately 30% of the body surface. The patient was started on intravenous methylprednisolone and oral cyclosporine. There were no additional blistering lesions after 10\u2009days of treatment, prompting a gradual dose reduction. Our case suggests that a stepwise vaccination adhering to the standard dosing schedule should be warranted with close monitoring for possible significant side effects.<\/jats:p>","DOI":"10.1111\/1346-8138.16808","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T06:29:26Z","timestamp":1682576966000},"page":"1190-1193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Rapidly progressing generalized bullous fixed drug eruption after the first dose of COVID\u201019 messenger RNA vaccination"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5264-130X","authenticated-orcid":false,"given":"Sooyeon","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul South 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Ho","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do\u2010Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-4579","authenticated-orcid":false,"given":"Tae\u2010Gyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital Yonsei University College of Medicine  Seoul South 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