{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:34:32Z","timestamp":1773956072117,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fosravuconazole L\u2010lysine ethanolate (F\u2010RVCZ) is an oral antifungal agent approved in Japan for the treatment of onychomycosis. We treated 36 patients (mean age 77.6\u2009years) with onychomycosis that had been refractory to long\u2010term topical treatment. The patients took F\u2010RVCZ (100\u2009mg ravuconazole) once daily for a mean of 11.3\u2009weeks, and were followed up for an average of 48\u2009weeks (mean 48.3\u2009\u00b1\u20092.1\u2009weeks). The mean rate of improvement of the affected nail area at 48\u2009weeks was 59.4%, and 12 patients achieved complete cure. Patients with total dystrophic onychomycosis (TDO) showed a significantly lower improvement rate than those with distal and lateral subungual onychomycosis (DLSO), and those with an affected nail area of 76%\u2013100% at the first visit showed a significantly lower improvement rate than those with an affected nail area of 0%\u201375%. Six patients had adverse events necessitating treatment discontinuation, but the symptoms and laboratory data improved without specific treatment in all of them. The data suggest that F\u2010RVCZ would be effective in various age groups, including the elderly, and even in patients with onychomycosis refractory to long\u2010term topical antifungal treatment. It was also suggested that its early use in mild cases might achieve a higher rate of complete cure. Furthermore, the average cost of oral F\u2010RVCZ therapy was lower than that for topical antifungal agents. Therefore, F\u2010RVCZ is considered to be much more cost\u2010effective than topical antifungal agents.<\/jats:p>","DOI":"10.1111\/1346-8138.16824","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T05:58:20Z","timestamp":1683611900000},"page":"1014-1019","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcome of fosravuconazole treatment for onychomycosis refractory to topical antifungal agents"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-7256","authenticated-orcid":false,"given":"Tsuyoshi","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Dermatology Iwate Medical University School of Medicine  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2357-7550","authenticated-orcid":false,"given":"Daisuke","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Iwate Medical University School of Medicine  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-6489","authenticated-orcid":false,"given":"Yuichiro","family":"Tsunemi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saitama Medical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroo","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Iwate Medical University School of Medicine  Iwate Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0403-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15618"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14935"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13816"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3314\/mmj.19-00009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00540-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15651"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14607"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4265\/bio.23.151"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14809"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T05:30:17Z","timestamp":1692336617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/1346-8138.16824"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16824","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,8]]},"assertion":[{"value":"2023-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}