{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:21:19Z","timestamp":1747747279310,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81130030","81000694"],"award-info":[{"award-number":["81130030","81000694"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7172214"],"award-info":[{"award-number":["7172214"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapy discontinuation of systemic glucocorticoid treatment for pemphigus remains uncertain at the clinical end point of complete remission. The objective of this study was\u00a0to identify the factors associated with achieving complete remission off therapy (CROT) and analyze the occurrence of relapse after therapy discontinuation. A retrospective cohort study was conducted at the Department of Dermatology of Peking University First Hospital. A total of 447 patients with pemphigus treated from 2005 to 2020 were identified. Univariate and multivariate analyses were conducted to analyze the associated factors of CROT and to evaluate the outcomes. The mean age was 48\u2009years (\u00b113.4\u2009years), and 54.6% of the patients were women. During a median follow\u2010up of 59 months (43\u201387.5\u2009months), 160 of 447 (35.8%) patients achieved CROT after a median treatment duration of 51 months (38\u201366.2\u2009months). Patients with a shorter therapy duration to complete remission on minimal therapy and negative desmoglein antibodies tested in remission were more likely to achieve early CROT. Thirty\u2010five of 160 (21.9%) patients experienced relapse after CROT. Patients who discontinued therapy without guidance experienced significantly\u00a0faster and higher occurrences of relapse than those withdrawing under guidance (log\u2010rank <jats:italic>p<\/jats:italic>\u2009=\u20090.01). Minimal therapy maintenance \u22648\u2009months from complete remission on minimal therapy and positive desmoglein antibodies tested at withdrawal increased the risk of early relapse after CROT.<\/jats:p>","DOI":"10.1111\/1346-8138.16838","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T07:59:47Z","timestamp":1685433587000},"page":"1347-1352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of clinical factors and outcome of systemic glucocorticoid therapy discontinuation in patients with pemphigus achieving complete remission"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8317-3414","authenticated-orcid":false,"given":"Mingyue","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panpan","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical 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Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birao","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing China"},{"name":"National Medical Products Administration Key Laboratory for Quality Control and Evaluation of Cosmetics  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyang","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Peking University First Hospital  Beijing China"},{"name":"National Clinical Research Center for Skin and Immune Diseases  Beijing China"},{"name":"Beijing Key Laboratory of Molecular Diagnosis on Dermatoses  Beijing 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