{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:32:21Z","timestamp":1792668741104,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20FC1004"],"award-info":[{"award-number":["20FC1004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["22FC1004"],"award-info":[{"award-number":["22FC1004"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydroa vacciniforme lymphoproliferative disorder (HV\u2010LPD) and severe mosquito bite allergy (SMBA) are both cutaneous forms of Epstein\u2013Barr virus (EBV)\u2010associated T\/natural killer (NK) cell LPDs and are closely related to chronic active EBV disease (CAEBV) and EBV\u2010associated hemophagocytic lymphohistiocytosis (EBV\u2010HLH). HV\u2010LPD is further divided into classic HV, a benign subtype mediated by EBV\u2010positive \u03b3\u03b4T cells, and systemic HV, another life\u2010threatening subtype mainly associated with EBV\u2010positive \u03b1\u03b2T or \u03b3\u03b4T cells. The vast majority of patients with SMBA have increased numbers of EBV\u2010infected NK cells in the blood. Clinical symptoms of HV\u2010LPD and SMBA often overlap in the same patient and may progress to more serious disease conditions equivalent to the systemic form of CAEBV. To define the disease spectrum of HV\u2010LPD and SMBA, we propose the diagnostic criteria and the determination criteria for disease severity. The proposed diagnostic criteria are consistent with those for CAEBV and EBV\u2010HLH in the guidelines for the management for CAEBV and related disorders 2023.<\/jats:p>","DOI":"10.1111\/1346-8138.16842","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T08:59:03Z","timestamp":1685437143000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2201-6129","authenticated-orcid":false,"given":"Yoji","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Dermatology, Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-9835","authenticated-orcid":false,"given":"Hideo","family":"Asada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nara Medical University School of Medicine Nara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5707","authenticated-orcid":false,"given":"Toshihisa","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare Narita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1553-2539","authenticated-orcid":false,"given":"Jun\u2010ichi","family":"Kawada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8063-5660","authenticated-orcid":false,"given":"Hiroshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Virology Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8275-5372","authenticated-orcid":false,"given":"Ayako","family":"Arai","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology, Department of Internal Medicine St. Marianna University School of Medicine Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-5279","authenticated-orcid":false,"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Kurume University Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-7792","authenticated-orcid":false,"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-3179","authenticated-orcid":false,"given":"Keiji","family":"Iwatsuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Committee for Guidelines for the Management of Chronic Active EBV Disease and Related Disorders (the MHLW Research Team in Japan)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"244","volume-title":"WHO Classification of Skin Tumours","author":"Quintanilla\u2010Martinez L","year":"2018"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.99812.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70120-3"},{"key":"e_1_2_12_5_1","first-page":"223","article-title":"Hypersensitivity to mosquito bites is not an allergic disease, but an Epstein\u2010Barr virus\u2010associated lymphoproliferative disease","volume":"72","author":"Ishihara S","year":"2000","journal-title":"Int J Hematol"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1699080"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01620-2"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015851"},{"key":"e_1_2_12_9_1","unstructured":"Japanese Society for Pediatric Infectious Disease.Guidelines for the Management of Chronic Active EBV Disease and Related Disorders (2023) SHINDAN TO CHIRYO SHA Inc. Tokyo.2023(in Japanese) 15\u201317."},{"key":"e_1_2_12_10_1","unstructured":"BazinP.Theoretical and clinical lessons on generic skin conditions (Le\u00e7ons th\u00e9oriques et cliniques sur les affections g\u00e9n\u00e9riques de la peau. tom1) 1862:p. 599."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02777.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.461"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20192262"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1086\/605610"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660230098020"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.5.587"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018893750"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.2.280"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-381921"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13411"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-502203"},{"key":"e_1_2_12_22_1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1684\/ejd.2018.3490","article-title":"Hydroa vacciniforme: a distinctive form of Epstein\u2010Barr virus\u2010associated T\u2010cell lymphoproliferative disorders","volume":"29","author":"Iwatsuki K","year":"2019","journal-title":"Eur J Dermatol"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0334-0"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23915.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114751"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.03.001"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25811"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.05083"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01094.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06038.x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23843"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-03-785931"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.710400"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01909-y"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26544"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.122"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T11:53:48Z","timestamp":1702554828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/1346-8138.16842"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16842","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]},"assertion":[{"value":"2023-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}