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The authors reported three cases of subcorneal pustular dermatosis. In case 1, a 9\u2010year\u2010old girl developed a skin rash with blisters following a mycoplasma infection and had a flare\u2010up due to a common cold. She was successfully treated with a topical corticosteroid. In case 2, a 70\u2010year\u2010old woman who had been treated for rheumatoid arthritis with adalimumab, salazosulfapyridine, and leflunomide developed 3\u2010 to 5\u2010mm pustules on her trunk and thighs 4\u2009days after flu vaccination. The rash disappeared with drug withdrawal and treatment with diaminodiphenyl sulfone. In case 3, an 81\u2010year\u2010old man, who was diagnosed with pyoderma gangrenosum at 61\u2009years old, developed multiple small flaccid pustules on his trunk and extremities due to an infection in the arteriovenous shunt area on the forearm. The pustule disappeared with intravenous antibiotic therapy; however, the pustules subsequently flared up along with ulcers typical of pyoderma gangrenosum. He was given oral prednisolone therapy, which was effective for the small pustules and some ulcers. Immunohistochemical examination of the three cases revealed neutrophilic infiltration in the subcorneal layer of the epidermis. The pustules contained neutrophils as well as some CD68<jats:sup>+<\/jats:sup> and a few CD1a<jats:sup>+<\/jats:sup> cells. The epidermis and dermis were more predominantly infiltrated by CD4<jats:sup>+<\/jats:sup> cells than by CD8<jats:sup>+<\/jats:sup> cells. Positive stainings for interleukin 8, interleukin 36\u03b3, and phospho\u2010extracellular signal\u2010regulated kinases 1 and 2 were observed in the upper layers of the epidermis below the pustules. Although the pathogenesis of subcorneal pustular dermatosis has not been clarified, the current results suggest that a variety of inflammatory cells, including those responsible for both innate and acquired immunity, are involved in the accumulation of neutrophils in subcorneal pustular dermatosis.<\/jats:p>","DOI":"10.1111\/1346-8138.16850","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T08:05:35Z","timestamp":1686211535000},"page":"1150-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Three cases of subcorneal pustular dermatosis with immunohistochemical examinations"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5136-1282","authenticated-orcid":false,"given":"Megumi","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Department of Dermatology Jichi Medical University  Shimotsuke Tochigi 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