{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T19:15:01Z","timestamp":1781118901720,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Little is known about biological outcomes for severe psoriasis in trisomy 21 (T21). Our aim was to review outcomes of patients with T21 and severe psoriasis treated with biologic or Janus kinase inhibitors (JAKi). Information on demographics, co\u2010morbidities, and therapeutic responses was retrospectively collated. Twenty\u2010one patients were identified (mean age 24.7\u2009years). Ninety percent (18\/20) of TNF\u03b1 inhibitor trials failed. Almost two\u2010thirds (7\/11) of patients achieved an adequate response with ustekinumab. All three patients treated with tofacitinib achieved an adequate response following at least three biologic failures. The mean number of biologic\/JAKi therapies received was 2.1 with overall survival of 36%. Eighty\u2010one percent (17\/21) of patients required conversion from their index biologic treatment due to failure. In patients with T21 and severe psoriasis, failure of TNF\u03b1 inhibition is common and ustekinumab therapy should be considered as first\u2010line therapy. The role of JAKi is emerging.<\/jats:p>","DOI":"10.1111\/1346-8138.16851","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T07:50:57Z","timestamp":1686210657000},"page":"1339-1342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biological and <scp>JAK<\/scp> inhibitor therapy outcomes for severe psoriasis in trisomy 21"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-5293","authenticated-orcid":false,"given":"Cathal","family":"O'Connor","sequence":"first","affiliation":[{"name":"Department of Dermatology South Infirmary Victoria University Hospital  Cork Ireland"},{"name":"Department of Medicine University College Cork  Cork 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