{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:27:05Z","timestamp":1768516025280,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with autoimmune bullous diseases (AIBDs) are considered to be immunocompromised and, consequently, they may be more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection and have poorer outcomes. However, the risk and repercussions of SARS\u2010CoV\u20102 infection in patients with AIBDs have not been fully understood. Therefore, we aimed to investigate the risk factors of SARS\u2010CoV\u20102 infection and the impact of SARS\u2010CoV\u20102 on patients with AIBDs. From December 2022 to January 2023, all patients with AIBDs who visited our clinic were enrolled in this study. Meanwhile, web\u2010based questionnaires and telesurveys were used as supplements. Information about patients' demographics, comorbidities, SARS\u2010CoV\u20102 infection, and vaccination, as well as AIBD status and treatments were collected and analyzed. The diagnosis of SARS\u2010CoV\u20102 infection was based on a positive polymerase chain reaction test, and\/or an antigen test, or the presence of typical symptoms in conjunction with an epidemiological history. Finally, 95 patients with AIBDs were enrolled, including 47 cases of pemphigus and 48 cases of pemphigoid cases, and 73 had symptoms consistent with coronavirus disease 2019. Common symptoms after SARS\u2010CoV\u20102 infection were fever (80.8%), fatigue (75.0%), cough (71.2%), muscle\/joint pain (49.3%), and sore throat (45.2%). No significant differences were found between SARS\u2010CoV\u20102\u2013infected and asymptomatic patients. Patients who had hypertension (<jats:italic>p<\/jats:italic>\u2009=\u20090.034), hyperlipidemia (<jats:italic>p<\/jats:italic>\u2009=\u20090.017), or more than two comorbidities (<jats:italic>p<\/jats:italic>\u2009=\u20090.011) were more likely to develop pneumonia after infection. Patients with pemphigus who did not achieve disease control (<jats:italic>p<\/jats:italic>\u2009=\u20090.045) or had an oral corticosteroid dose \u226515\u2009mg\/day (<jats:italic>p<\/jats:italic>\u2009=\u20090.024) and patients with pemphigoid with a disease duration \u22652\u2009years (<jats:italic>p<\/jats:italic>\u2009=\u20090.037) were more prone to AIBDs aggravation. In conclusion, patients with AIBDs are generally susceptible to SARS\u2010CoV\u20102 infection. Individuals with newly diagnosed AIBDs, uncontrolled disease, and a higher corticosteroid dose are more susceptible to disease exacerbation.<\/jats:p>","DOI":"10.1111\/1346-8138.16900","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T05:26:18Z","timestamp":1690521978000},"page":"1433-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Severe acute respiratory syndrome coronavirus 2 infection in patients with autoimmune bullous diseases in China"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0840-2004","authenticated-orcid":false,"given":"Jia\u2010Ling","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4947-2899","authenticated-orcid":false,"given":"Si\u2010Hang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng\u2010Nan","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Zhe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8280-7291","authenticated-orcid":false,"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2526-4331","authenticated-orcid":false,"given":"Ya\u2010Gang","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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