{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:03:55Z","timestamp":1785769435645,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T00:00:00Z","timestamp":1690675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of antipsoriatic therapy on cardio\u2010cerebrovascular disease (CCVD) is not well described. Thus, we performed a population\u2010based nested case\u2013control study to investigate the effect of systemic antipsoriatic therapy on CCVD in psoriasis patients. Using nationwide cohort data from the Korean National Health Insurance Claims database, newly diagnosed psoriasis patients were identified. Among the enrolled participants, postenrollment development of CCVD events (ischemic heart disease, myocardial infarction, cerebral infarction, and cerebral hemorrhage) was investigated. To evaluate the effect of systemic antipsoriatic therapy on CCVD risk, we calculated the proportion of the treatment period with systemic antipsoriatic therapy during the study period (PTP [%]: the sum of all systemic antipsoriatic therapy durations divided by total observation period). Among 251\u2009813 participants, 6262 experienced CCVD events during the study period (CCVD group). Controls included 245\u2009551 patients without CCVD history during the study period (non\u2010CCVD group). The non\u2010CCVD group had greater PTP than the CCVD group (CCVD 2.12\u2009\u00b1\u20097.92, non\u2010CCVD 2.64\u2009\u00b1\u20099.64; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In multiple logistic regression analysis, PTP was inversely associated with the CCVD risk after adjusting for age, sex, diabetes, hypertension, and dyslipidemia. A 10% increase in PTP reduced CCVD risk by 0.96 (95% confidence interval 0.93 to 0.99). Reduced CCVD risk was robust for both conventional antipsoriatic therapy and biologics. Our study found that systemic antipsoriatic therapy use was inversely associated with CCVD risk in psoriasis patients. These findings suggested that systemic antipsoriatic therapy could reduce CCVD development in patients with psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.16904","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T05:17:42Z","timestamp":1690780662000},"page":"1442-1449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between cardio\u2010cerebrovascular disease and systemic antipsoriatic therapy in psoriasis patients using population\u2010based data: A nested case\u2013control study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-1606","authenticated-orcid":false,"given":"Bo Ri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4073-6428","authenticated-orcid":false,"given":"Kun Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Applied Statistics Yonsei University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9403-605X","authenticated-orcid":false,"given":"Jinseob","family":"Kim","sequence":"additional","affiliation":[{"name":"Zarathu Co., Ltd.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1618-7327","authenticated-orcid":false,"given":"Jee Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5706-2371","authenticated-orcid":false,"given":"Kyungho","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul National University Bundang Hospital  Seongnam Republic of Korea"},{"name":"Department of Dermatology Seoul National University College of Medicine  Seoul Republic of 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