{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:24:53Z","timestamp":1789604693586,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperhidrosis is a chronic skin condition characterized by excessive sweating. It poses a burden on affected people, reducing their quality of life and productivity. We undertook a targeted literature review (TLR) to gather current evidence on the epidemiology as well as the human and economic burden posed on patients with hyperhidrosis. Searches were performed in Medline database (access via OVID interface) and ICHUSHI database. Articles published between January 2000 and September 2020 that analyzed at least 50 patients were included. Sixty\u2010four publications were identified and 38 publications covering a unique domain were selected to inform this TLR. The incidence of hyperhidrosis ranged from 0.13% in the UK to 0.28% in the USA, with a higher rate in females. The prevalence of hyperhidrosis varied from 2.8%\u20134.8% in the US general population to 18.40% in Chinese inpatients, while the prevalence of axillary hyperhidrosis varied from 1.4% in the US general population to 5.75% in Japanese employees\/students. Due to excessive sweating, hyperhidrosis was reported to be a moderate\u2010to\u2010extreme limitation at work for the US patients, with 33.5% feeling unhappy. Patients' satisfaction was high post\u2010treatment. Considerable costs were related to the treatment with botulinum toxin and surgery. Hospital stays for surgery lasted from 10\u2009h to 3\u2009days. The percentage of patients who sought a medical consultation varied from 6.3% for Japanese patients with primary focal hyperhidrosis to 51% for the US general population with any type of hyperhidrosis. There is limited evidence of the hyperhidrosis burden, particularly among Japanese patients; however, the burden was high and limited patients' daily functioning. Future actions should include implementation of educational programs to raise awareness of the condition, conduct of larger studies, and generation of more evidence. Understanding the nature of hyperhidrosis and the burden it poses is of utmost importance.<\/jats:p>","DOI":"10.1111\/1346-8138.16908","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T07:25:17Z","timestamp":1690788317000},"page":"1227-1236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hyperhidrosis: A targeted literature review of the disease burden"],"prefix":"10.1111","volume":"50","author":[{"given":"Yuichiro","family":"Oshima","sequence":"first","affiliation":[{"name":"Department of Dermatology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0771-3778","authenticated-orcid":false,"given":"Tomoko","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Ikebukuro Nishiguchi Fukurou Dermatology Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Nomoto","sequence":"additional","affiliation":[{"name":"Creativ\u2010Ceutical  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Fukui","sequence":"additional","affiliation":[{"name":"Maruho Co., Ltd.  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Maruho Co., Ltd.  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446786"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37562017000000379"},{"key":"e_1_2_7_4_1","first-page":"729","article-title":"Hyperhidrosis: management options","volume":"97","author":"McConaghy JRFD","year":"2018","journal-title":"Am Fam Physician"},{"key":"e_1_2_7_5_1","first-page":"32","article-title":"Hyperhidrosis\u2014causes and treatment of enhanced sweating. Deutsches \u00c4rzteblatt","volume":"106","author":"Tanja Schlereth MD","year":"2009","journal-title":"Dermatol Int"},{"key":"e_1_2_7_6_1","first-page":"1379","article-title":"Guidelines for the treatment of primary focal hyperhidrosis: a revised version 2015","volume":"125","author":"Association JD","year":"2015","journal-title":"J Jpn Dermatol Assoc"},{"key":"e_1_2_7_7_1","unstructured":"Exchange rate for March 2023 Bank of Japan;2023Available from:https:\/\/www.boj.or.jp\/about\/services\/tame\/tame_rate\/kijun\/kiju2303.htm"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00439-y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.5.772"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.10.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000287"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1697-9"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153719"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0259-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.06.006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2012.09.002"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351292"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12258"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000339128.13935.0E"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00029330-200712020-00011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2007.01.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.12.040"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.04.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-013-1692-7"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.15-00241"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-011-9738-4"},{"key":"e_1_2_7_27_1","first-page":"82","article-title":"Hyperhidrosis: focusing on hyperhidrosis of the palms and soles, consideration of the degree of mental improvement and psychogenic sweating before and after treatment for palmar and plantar hyperhidrosis","volume":"22","author":"Fujimoto T","year":"2015","journal-title":"Jpn J Perspir Res"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2014.04.0108"},{"key":"e_1_2_7_29_1","first-page":"10","article-title":"Endoscopic thoracic sympathectomy","volume":"26","author":"Hayashi M","year":"2008","journal-title":"Physiol Soc Jpn"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-013-0025-y"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-2896(04)75475-7"},{"key":"e_1_2_7_32_1","first-page":"57","article-title":"Device and evaluation of thoracic sympathectomy","volume":"9","author":"Ohta M","year":"2004","journal-title":"J Jpn Soc Endosc Surg"},{"key":"e_1_2_7_33_1","first-page":"423","article-title":"Safety and Efficicacy of botulinum toxin type a (BOTOX) in patients with severe Primay axillary hyperhidrosis: results of special drug use investigation","volume":"39","author":"Onaka Y","year":"2019","journal-title":"Prog Med"},{"key":"e_1_2_7_34_1","first-page":"80","article-title":"Current status of day surgery in palmar hyperhidrosis","volume":"16","author":"Sada M","year":"2009","journal-title":"Jpn J Perspir Res"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta21800"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34132.x"},{"key":"e_1_2_7_37_1","first-page":"11","article-title":"Are treatment guidelines for palmar hyperhidrosis in line with actual practice? From surgeons' perspective","volume":"19","author":"Yokoyama T","year":"2012","journal-title":"Jpn J Perspir Res"},{"key":"e_1_2_7_38_1","first-page":"6","article-title":"Indication of endoscopic thoracic sympathectomy for palmer hyperhidrosis","volume":"21","author":"Yoshioka H","year":"2014","journal-title":"Jpn J Perspir Res"},{"key":"e_1_2_7_39_1","first-page":"49","article-title":"Thoracoscopic thoracic sympathetic nerve blockade for palmoplantar hyperhidrosis: efficacy assessment by preoperative and postoperative sweating tests","volume":"17","author":"Yoshioka H","year":"2010","journal-title":"Jpn J Perspir Res"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3079-0"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2015.05.002"},{"key":"e_1_2_7_42_1","first-page":"33","article-title":"Pathogenesis and stepwise treatment of primary focal hyperhidrosis","volume":"17","author":"Tanaka T","year":"2010","journal-title":"Jpn J Persp Res"},{"key":"e_1_2_7_43_1","first-page":"3","article-title":"Current status of palmar hyperhidrosis surgery in our hospital","volume":"15","author":"Nishiyama K","year":"2009","journal-title":"J Saiseikai Suita"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.06.052"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05059.x"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-022-02365-9"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16050"},{"key":"e_1_2_7_48_1","first-page":"431","article-title":"Survey on awareness of axillary hyperhidrosis: results of internet questionnaire survey in 608 individuals","volume":"39","author":"Fujimoto T","year":"2022","journal-title":"J Jpn Org Clin Dermatol"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2020.1855879"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:20:03Z","timestamp":1696411203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,31]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/1346-8138.16908"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16908","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,31]]},"assertion":[{"value":"2022-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}