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The genetic instruments of MetS and its five components (waist circumference [WC], hypertension, fasting blood glucose [FBG], triglycerides [TG], and high\u2010density lipoprotein cholesterol [HDL\u2010C]) were obtained from public genome\u2010wide association studies (GWAS). Outcome datasets for psoriasis were collected from the FinnGen Biobank Analysis Consortium. The main method was inverse variance weighting, complemented by sensitivity approaches to rectify potential pleiotropy. MetS, WC, and hypertension increase the risk of psoriasis (MetS, odd ratios [OR]\u2009=\u20091.17, 95% confidence interval [CI] 1.08\u20131.27, <jats:italic>p<\/jats:italic>\u2009=\u20091.23e\u201004; WC, OR\u2009=\u20091.65, 95% CI\u2009\u20091.42\u20131.93, <jats:italic>p<\/jats:italic>\u2009=\u20091.06e\u201010; hypertension, OR\u2009=\u20092.02, 95% CI\u20091.33\u20133.07, <jats:italic>p<\/jats:italic>\u2009=\u20090.0009). In the reverse analysis, no causal association between psoriasis and MetS and its five components was identified. We provide novel genetic evidence that MetS, WC, and hypertension are risk factors for the development of psoriasis. Early management of MetS and its components may be an effective strategy to decrease the risk of psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.16910","type":"journal-article","created":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T04:44:22Z","timestamp":1690951462000},"page":"1392-1400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic insights into the risk of metabolic syndrome and its components on psoriasis: A bidirectional Mendelian randomization"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7406-5006","authenticated-orcid":false,"given":"Liming","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Modern Hospital of Sichuan  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Modern Hospital of Sichuan  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Modern Hospital of Sichuan  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhe","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Modern Hospital of Sichuan  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"385","article-title":"Epidemiology of psoriasis. 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