{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:29Z","timestamp":1747182029012,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A dermatophyte antigen kit (DQT) was released in Japan as an in vitro diagnostic tool to identify tinea unguium in June 2022. From July 2022 to February 2023, we examined 75 potassium hydroxide (KOH)\u2010negative patients (male, <jats:italic>n<\/jats:italic>\u2009=\u200923; female, <jats:italic>n<\/jats:italic>\u2009=\u200952; mean \u00b1 SD age, 63.6\u2009\u00b1\u200913.9\u2009years) and determined the accuracy in confirming the fungal element with ZoomBlue\u2122 staining at 400\u00d7 magnification. The DQT results were classified into three categories. DQT\u2010positive onychomycosis was detected in 27 patients with tinea unguium and two with non\u2010dermatophyte onychomycosis. Fungal cultures were positive in 14 (51.8%) patients (<jats:italic>Trichophyton rubrum<\/jats:italic> [<jats:italic>n<\/jats:italic>\u2009=\u200911], <jats:italic>T.\u2009interdigitale<\/jats:italic> [<jats:italic>n<\/jats:italic>\u2009=\u20091], <jats:italic>Fusarium solani<\/jats:italic> [<jats:italic>n<\/jats:italic>\u2009=\u20091], and <jats:italic>Talaromyces muroii<\/jats:italic> [<jats:italic>n<\/jats:italic>\u2009=\u20091]). DQT\u2010negative onychomycosis included ten patients with cured tinea unguium and 3 with <jats:italic>Candida<\/jats:italic> onychomycosis. Twenty\u2010three patients had DQT\u2010negative mimics for onychomycosis (onychauxis [<jats:italic>n<\/jats:italic>\u2009=\u200911], traumatic onycholysis [<jats:italic>n<\/jats:italic>\u2009=\u20098], yellow nail syndrome [<jats:italic>n<\/jats:italic>\u2009=\u20095], pincer nail deformity [<jats:italic>n<\/jats:italic>\u2009=\u20093], brittle nail syndrome [<jats:italic>n<\/jats:italic>\u2009=\u20092], contact dermatitis [<jats:italic>n<\/jats:italic>\u2009=\u20092], lichen planus [<jats:italic>n<\/jats:italic>\u2009=\u20091] and psoriasis [<jats:italic>n<\/jats:italic>\u2009=\u20091]). Because sparse, atrophic and\/or fragmented mycelia are invisible in direct microscopy with potassium hydroxide (KOH) at 100\u00d7 magnification, DQT was beneficial for diagnosing onychomycosis.<\/jats:p>","DOI":"10.1111\/1346-8138.16924","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:28:53Z","timestamp":1692682133000},"page":"1614-1618","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dermatophyte antigen kit: A useful diagnostic tool for onychomycosis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-304X","authenticated-orcid":false,"given":"Hiromitsu","family":"Noguchi","sequence":"first","affiliation":[{"name":"Noguchi Dermatology Clinic  Kumamoto Japan"},{"name":"Ochanomizu Institute for Medical Mycology and Allergology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-4612","authenticated-orcid":false,"given":"Tadahiko","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Noguchi Dermatology Clinic  Kumamoto Japan"},{"name":"Ochanomizu Institute for Medical Mycology and Allergology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Mimura","sequence":"additional","affiliation":[{"name":"Noguchi Dermatology Clinic  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahide","family":"Kubo","sequence":"additional","affiliation":[{"name":"Noguchi Dermatology Clinic  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Defense Medical College  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3801-809X","authenticated-orcid":false,"given":"Kayo","family":"Kashiwada\u2010Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9217-1805","authenticated-orcid":false,"given":"Utako","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataro","family":"Hiruma","sequence":"additional","affiliation":[{"name":"Ochanomizu Institute for Medical Mycology and Allergology  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Plastic Surgery, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12660"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13348"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08523.x"},{"key":"e_1_2_6_5_1","first-page":"37","volume-title":"Onychomycosis: the current approach to diagnosis and therapy","author":"Baran 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