{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:29Z","timestamp":1747182029753,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Fusarium<\/jats:italic> species (spp.) is frequently found in soil and plant residues and on plant bodies in all climatic zones worldwide. Although there have been few reports of onychomycosis caused by <jats:italic>Fusarium<\/jats:italic> spp., it is characterized by drug sensitivity and other characteristics. Here, we report what may be the first case of onychomycosis caused by <jats:italic>Fusarium lactis<\/jats:italic>. We analyzed the mycology and characterized previously reported cases of onychomycosis caused by <jats:italic>Fusarium<\/jats:italic> spp. A 73\u2010year\u2010old otherwise healthy woman presented with discoloration and thickening of her right thumbnail with paronychia. Direct microscopy revealed unevenly swollen hyphae, and a Grocott\u2010stained nail specimen showed septate hyphae. Based on the morphological features and gene analysis of fungus isolated from the nail, we diagnosed onychomycosis caused by <jats:italic>F. lactis<\/jats:italic> belonging to <jats:italic>Fusarium fujikuroi<\/jats:italic> species complex. Partial nail removal and topical application of 1% luliconazole solution resolved the condition in 6 months. Minimum inhibitory concentrations for isolated <jats:italic>F. lactis<\/jats:italic> showed high sensitivity to luliconazole but not itraconazole or terbinafine. The isolated <jats:italic>F. lactis<\/jats:italic> was temperature\u2010sensitive. A search of the literature revealed 57 cases of onychomycosis caused by <jats:italic>Fusarium<\/jats:italic> spp. with delineated clinical characteristics. Since those cases were investigated using morphological and\/or molecular methods, we analyzed them by species complex as well as species. Onychomycosis caused by <jats:italic>Fusarium<\/jats:italic> spp. is predominantly found on the big toe, with <jats:italic>Fusarium solani<\/jats:italic> species complex and <jats:italic>Fusarium\u2009oxysporum<\/jats:italic> species complex accounting for over 70% of cases. Infection of only one digit with paronychia is a characteristic clinical manifestation of onychomycosis caused by <jats:italic>Fusarium<\/jats:italic> spp. Since there has been an increase in instances of molecular determination of <jats:italic>Fusarium<\/jats:italic> spp., it is deemed necessary to clarify its clinical and fungal nature. Due to its characteristic drug sensitivity and temperature\u2010sensitive nature, new treatments are expected to be developed.<\/jats:p>","DOI":"10.1111\/1346-8138.16931","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T08:45:20Z","timestamp":1692953120000},"page":"1550-1559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Possibly the first case of onychomycosis by <i>Fusarium lactis<\/i>: Case presentation and literature review of onychomycosis by <i>Fusarium<\/i> species"],"prefix":"10.1111","volume":"50","author":[{"given":"Fumiaki","family":"Taga","sequence":"first","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Anzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-618X","authenticated-orcid":false,"given":"Taketoshi","family":"Futatsuya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7084-1567","authenticated-orcid":false,"given":"Reimon","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-8201","authenticated-orcid":false,"given":"Kiminobu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-980X","authenticated-orcid":false,"given":"Takashi","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7742-079X","authenticated-orcid":false,"given":"Akira","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University  Kahoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10327-021-01011-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/07060660909507571"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-03-11-0157"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00649-17"},{"volume-title":"Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard, 2nd ed. CLSI document M38\u2010A2, 2nd ed","year":"2008","author":"CLSI","key":"e_1_2_7_6_1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/158.5.1046"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.5.1167"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2941"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03498.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12420"},{"key":"e_1_2_7_12_1","article-title":"Onychomycosis caused by fusarium oxysorum on the squamous cell carcinoma","volume":"98","author":"Minami K","year":"1988","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_13_1","article-title":"Two cases of onychomycosis caused by Fusarium verticillioides","volume":"52","author":"Miyasato Y","year":"2011","journal-title":"Med Mycol J"},{"key":"e_1_2_7_14_1","first-page":"191","article-title":"Disseminated Fusarium infection originating from paronychia in a neutropenic patient: a case report and review of the literature","volume":"85","author":"Bourgeois GP","year":"2010","journal-title":"Cutis"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06692.x"},{"key":"e_1_2_7_16_1","first-page":"1","article-title":"Taxonomic system of the genus Fusarium","volume":"25","author":"Aoki T","year":"2009","journal-title":"Microbiol Cult Coll"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12638"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2008.01619.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2007.03120.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13570"},{"key":"e_1_2_7_21_1","first-page":"541","article-title":"A case of onychomycosis caused by Fusarium verticillioides","volume":"73","author":"Yamaguchi R","year":"2019","journal-title":"Jpn J Clin Dermatol"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15358"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12580"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.68.652"},{"key":"e_1_2_7_25_1","article-title":"A case of onychomycosis caused by Fusarium solani","volume":"120","author":"Nakamura Y","year":"2010","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_26_1","first-page":"683","article-title":"Onychomycosis caused by Fusarium solani successfully treated with itraconazole","volume":"54","author":"Nomoto M","year":"2012","journal-title":"Rinsho Derma (Tokyo)"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myad015"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.5791547.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.1997.tb00184.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12906"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-005-0136-9"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0953756204000577"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04013.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14643"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12854"},{"key":"e_1_2_7_36_1","article-title":"A case of onychomycosis caused by Fusarium solani","volume":"4","author":"Ishida T","year":"2005","journal-title":"Skin Res"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3314\/jjmm1960.5.114"},{"key":"e_1_2_7_38_1","article-title":"Onychomycosis caused by Fusarium oxysporum","volume":"10","author":"Watanabe S","year":"1969","journal-title":"Jpn J Med Mycol"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2015.12.003"},{"key":"e_1_2_7_40_1","article-title":"Two cases of Fusarium solani detected in fingernails","volume":"60","author":"Miyauchi S","year":"1998","journal-title":"Nishinihon J Dermatol"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:MYCO.0000024186.32367.d4"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2009.01788.x"},{"key":"e_1_2_7_43_1","first-page":"999","article-title":"Cutaneous and onychomycosis caused by Fusarium oxysporum in erythromelalgia","volume":"46","author":"Higuchi M","year":"1984","journal-title":"Nishinihon J Dermatol"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T14:20:59Z","timestamp":1730902859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,25]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/1346-8138.16931"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16931","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2023,8,25]]},"assertion":[{"value":"2023-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}