{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:49:15Z","timestamp":1787237355624,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A case of cytoplasmic anaplastic lymphoma kinase (ALK)\u2010positive anaplastic large cell lymphoma (ALCL) initially involving the skin in a 44\u2010year\u2010old Japanese female is reported. The patient had a hemorrhagic erythematous tumor on the right thigh without any systemic symptoms. Pathology showed diffuse infiltration of CD30\u2010positive anaplastic large cells positive for epithelial membrane antigen and cytoplasmic ALK. The right inguinal lymph node showed infiltration of tumor cells in the marginal sinus. Only 2\u2009weeks after radiation therapy, the patient developed multiple subcutaneous nodules and lung involvement. Even after subsequent multichemotherapy sessions, cutaneous recurrence occurred. Literature review of cytoplasmic ALK\u2010positive ALCL initially involving in the skin revealed that skin lesions were mostly seen in the extremities and that half of the cases developed extracutaneous lesions. Radiation and chemotherapy were effective for most cases. Inverse RT\u2010PCR identified a\n                    <jats:italic>tumor necrosis factor receptor\u2010associated factor (TRAF)1<\/jats:italic>\n                    \u2010\n                    <jats:italic>ALK<\/jats:italic>\n                    fusion in our case. Most reported cases with this translocation experienced repeated changes in chemotherapy, suggesting poorer prognosis. Although ALK\u2010positive ALCL generally responds well to chemotherapy, the presence of a\n                    <jats:italic>TRAF1<\/jats:italic>\n                    \u2010\n                    <jats:italic>ALK<\/jats:italic>\n                    fusion may suggest resistance to treatment. Detection of fusion partners of\n                    <jats:italic>ALK<\/jats:italic>\n                    is important for predicting clinical courses and deciding treatment options.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.16981","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:55:43Z","timestamp":1695786943000},"page":"120-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Detection of\n                    <scp>\n                      <i>TRAF1\u2010ALK<\/i>\n                    <\/scp>\n                    fusion in skin lesions of systemic\n                    <scp>ALK<\/scp>\n                    + anaplastic large cell lymphoma initially involving the skin and the draining lymph node"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7649-0806","authenticated-orcid":false,"given":"Yuta","family":"Norimatsu","sequence":"first","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Akatsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akari","family":"Matsuoka","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5707","authenticated-orcid":false,"given":"Toshihisa","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Pathology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Pathology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Hematology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Onishi","sequence":"additional","affiliation":[{"name":"Department of Radiology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Togashi","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology Project of Molecular Targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihito","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology Project of Molecular Targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Pathology Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Pathology Project of Molecular Targets Cancer Institute, Japanese Foundation for Cancer Research  Tokyo Japan"},{"name":"Department of Pathology Cancer Institute Hospital, Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-329X","authenticated-orcid":false,"given":"Makoto","family":"Sugaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology International University of Health and Welfare  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO Classification of Tumours Editorial Board. Haematolymphoid tumours [internet; beta version ahead of print]. Lyon (France): International Agency for Research on Cancer;2022[cited 2023 Sep 11]. (WHO classification of tumours series 5th ed.; vol. 11). Available from:https:\/\/tumourclassification.iarc.who.int\/chapters\/63. (Subscription required)"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1997.tb01090.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04295.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05987.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-010-0708-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181648d6d"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.065664"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13688"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001449"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-3248"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.54.225"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1277-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00730"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-126541"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.16981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:40:25Z","timestamp":1705466425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.16981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/1346-8138.16981"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.16981","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]},"assertion":[{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}