{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:46:54Z","timestamp":1765889214360,"version":"3.28.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acetylcysteine (AC) destabilizes keratin and softens nails, reducing the time needed to correct pincer nail deformity with an overcurvature\u2010correcting device. The objective of this phase 3, multicenter, randomized, investigator\u2010blinded study was to evaluate the early and sustained therapeutic effectiveness and safety of 10% AC gel plus an overcurvature\u2010correcting device to treat pincer nails. Patients aged 12\u2009years and older with hallux pincer nail were fitted with an overcurvature\u2010correcting device for 7\u2009days, with a 24\u2010h application of AC gel (<jats:italic>n<\/jats:italic>\u2009=\u200940) or vehicle (<jats:italic>n<\/jats:italic>\u2009=\u200939) on day 1. The primary end point (achievement of a distal narrowed nail width ratio \u226570% on day 8) was met by 47.5% in the 10% AC group and 25.6% in the vehicle group (difference 21.9%;<jats:italic>p<\/jats:italic>\u2009=\u20090.0439). Secondary end points showed a greater tendency towards improvement with 10% AC. The nail correction effect was maintained for at least 12\u2009weeks in the majority of AC\u2010treated patients, although the study duration was insufficient to assess the long\u2010term probability of recurrence. No AC\u2010related adverse events were reported. In conclusion, a single application of 10% AC gel combined with short\u2010term device use facilitated earlier correction of pincer nails compared with the device alone, with improvements maintained after device removal.<\/jats:p>","DOI":"10.1111\/1346-8138.17010","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:19:32Z","timestamp":1701130772000},"page":"23-29","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Improvements in pincer nail deformity occur earlier and last longer when acetylcysteine gel is added to an overcurvature\u2010correcting device: Results of a phase 3, multicenter, randomized, vehicle\u2010controlled, investigator\u2010blinded study"],"prefix":"10.1111","volume":"51","author":[{"given":"Masataka","family":"Saito","sequence":"first","affiliation":[{"name":"Medical Corporation Shinanokai Shinanozaka Clinic Shinjuku\u2010ku Tokyo Japan"},{"name":"Department of Dermatology Keio University School of Medicine Shinjuku\u2010ku, Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Ikoma","sequence":"additional","affiliation":[{"name":"Maruho Co., Ltd. Kita\u2010ku Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Fujikawa","sequence":"additional","affiliation":[{"name":"Maruho Co., Ltd. Shimogyo\u2010ku Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Maruho Co., Ltd. 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