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There are various therapies, including surgery, radiation, systemic steroids, and immune suppressants, but their efficacy remains moderate due to the high recurrence rate. Biologics, like monoclonal antibodies, have shown tremendous effectiveness for chronic inflammatory diseases. Omalizumab is a monoclonal antibody against IgE and has not been approved for KD so far. We describe two refractory KD cases that responded to a small dose of steroids plus omalizumab. Additionally, we reviewed another 13 KD cases that were treated with biologics, including omalizumab, rituximab, dupilumab, and mepolizumab. The results indicate that biologics provide an alternative treatment strategy for KD.<\/jats:p>","DOI":"10.1111\/1346-8138.17021","type":"journal-article","created":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T07:15:21Z","timestamp":1699686921000},"page":"602-606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010immunoglobulin E provides an additional therapy to conventional steroids for Kimura's disease"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0661-1765","authenticated-orcid":false,"given":"Suiting","family":"Ao","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital, Sun Yat\u2010sen University  Guangzhou Guangdong China"},{"name":"Shandong Provincial Hospital for Skin Diseases &amp; Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University &amp; Shandong Academy of 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