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Their pathogenesis is complex, rooted in significant imbalances in both innate and adaptive immune systems, particularly featuring elevated levels of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interleukin (IL)\u20101, IL\u20108, IL\u201017, and IL\u201023. Studies involving skin tissue pathology and serology have indicated that targeting specific cytokines can bring therapeutic benefits. Indeed, many patients in clinical settings have responded positively to such interventions. Yet, given the diverse cytokines in play, focusing on a single one with antibody therapy might not always be effective. When resistance to biologics emerges, a combined approach targeting multiple overactive cytokines with immunosuppressants, for example cyclosporine and Janus kinase inhibitors, could be an option. In the current review, we explore recent therapeutic developments for PG and HS.<\/jats:p>","DOI":"10.1111\/1346-8138.17031","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:31:11Z","timestamp":1701131471000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["New treatment of pyoderma gangrenosum and hidradenitis suppurativa: A review"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3055-5202","authenticated-orcid":false,"given":"Keiichi","family":"Yamanaka","sequence":"first","affiliation":[{"name":"Department of Dermatology Mie University Graduate School of Medicine  Tsu 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