{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:39:31Z","timestamp":1765370371917,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous squamous cell carcinoma is usually treated with surgery; however, locoregionally advanced cutaneous squamous cell carcinoma can be difficult to resect. Although recent guidelines from Western countries recommend using anti\u2013programmed cell death protein 1 (PD\u20101) antibodies, including cemiplimab and pembrolizumab, there are no approved anti\u2013PD\u20101 antibodies for locoregional cutaneous squamous cell carcinoma in Asian countries. S\u20101 is an oral drug with a low incidence of severe toxicity that can be used for head and neck cancers, including head and neck locoregional cutaneous squamous cell carcinoma, in Japan. We retrospectively evaluated patients with head and neck locoregional cutaneous squamous cell carcinoma treated with S\u20101 at two Japanese institutions (2008\u20132022). The initial dosage was determined by the body surface area (&lt;1.25\u2009m<jats:sup>2<\/jats:sup>: 80\u2009mg\/day, 1.25\u20131.5\u2009m<jats:sup>2<\/jats:sup>: 100\u2009mg\/day, \u22651.5\u2009m<jats:sup>2:<\/jats:sup> 120\u2009mg\/day) for 28 consecutive days. The outcome measures were objective response rate (ORR), progression\u2010free survival (PFS), and overall survival (OS). Fourteen patients were included. The ORR was 78%, and the complete response (CR) rate was 64.3%. The median PFS and OS were not reached (NR) (95% confidence interval [CI], 5.9\u2009months\u2013NR) and NR (95% CI, 13.8\u2009months\u2013NR), respectively. The 12\u2010month PFS and OS rates were 51% and 85%, respectively. Six of the nine patients who achieved CR showed no recurrence during the follow\u2010up period (median follow\u2010up, 24.7\u2009months). After CR, three patients experienced recurrence. Among these, two resumed S\u20101 treatment and subsequently underwent salvage surgery, resulting in a sustained absence of recurrence. One patient developed lung metastasis and died, although S\u20101 therapy was resumed. Only one patient (7.1%) developed grade 3 anemia. S\u20101 showed favorable efficacy and low toxicity in patients with head and neck locoregionally advanced cutaneous squamous cell carcinoma. S\u20101 may be a good alternative to the anti\u2013PD\u20101 antibody for treating head and neck locoregionally advanced squamous cell carcinoma.<\/jats:p>","DOI":"10.1111\/1346-8138.17057","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:30:19Z","timestamp":1701131419000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Favorable efficacy of S\u20101 treatment for locoregionally advanced cutaneous squamous cell carcinoma in the head and neck region"],"prefix":"10.1111","volume":"51","author":[{"given":"Teruaki","family":"Izumi","sequence":"first","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center  Saitama Japan"},{"name":"Department of Dermatology Showa University  Tokyo 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