{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:48Z","timestamp":1747182048627,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DiGeorge syndrome, also known as 22q11.2 deletion syndrome, shows cellular immunodeficiency due to by thymic hypoplasia and hypocalcemia caused by hypoparathyroidism. It was reported that erythrodermic psoriasis occurred in a patient with 22q11 deletion syndrome. Here, we report the first case of DiGeorge syndrome presenting with a severe palmoplantar pustulosis (PPP)\u2010like eruption with extra\u2010palmoplantar lesions on the distal limbs. Given that PPP is a subtype of pustular psoriasis, the pustular eruption may be associated with DiGeorge syndrome. We measured serum levels of citrullinated histone H3 (CitH3), a representative marker of neutrophil extracellular traps, interleukin (IL)\u20108, and IL\u201022 and compared them with nine cases of typical PPP. In the PPP patients, the three markers were higher than in healthy subjects with significant correlations between CitH3 and IL\u20108\/IL\u201022. In our patient, CitH3, IL\u20108, and IL\u201022 were also high, and IL\u201022 was remarkably elevated compared with the PPP patients. Our case suggests that a certain T cell abnormality associated with DiGeorge syndrome induces IL\u201022 overproduction, leading to the PPP\u2010like eruption with extra\u2010 palmoplantar lesions.<\/jats:p>","DOI":"10.1111\/1346-8138.17065","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T10:22:43Z","timestamp":1702981363000},"page":"731-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["DiGeorge syndrome presenting with palmoplantar pustules: Comparative analysis of serum IL\u201022, NETs and IL\u20108 with usual palmoplantar pustulosis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3048-2381","authenticated-orcid":false,"given":"Yasuaki","family":"Ogura","sequence":"first","affiliation":[{"name":"Department of Dermatology &amp; Skin Oncology Chutoen General Medical Center  Kakegawa Japan"},{"name":"Allergic Disease Research Center Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumpei","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Skin Oncology Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Skin Oncology Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Skin Oncology Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Inuzuka","sequence":"additional","affiliation":[{"name":"Inuzuka Dermatology Clinic  Fukuroi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Skin Oncology Chutoen General Medical Center  Kakegawa Japan"},{"name":"Allergic Disease Research Center Chutoen General Medical Center  Kakegawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)81796-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(82)80116-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13724"},{"key":"e_1_2_6_5_1","first-page":"275","article-title":"Severe erythrodermic psoriasis in a patient with 22q11 deletion syndrome","volume":"100","author":"Preiss JC","year":"2005","journal-title":"Med Klin"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6252138"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00746"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14850"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1935.01470060002001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12248"},{"key":"e_1_2_6_11_1","first-page":"1","article-title":"Effect of guselkumab on serum biomarkers in Japanese palmoplantar pustulosis patients in a randomized","volume":"2","author":"Morita A","year":"2022","journal-title":"JEADV Clin Pract"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16181"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7888\/juoeh.32.317"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03511.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01325.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2010.10.013"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T13:39:52Z","timestamp":1714657192000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/1346-8138.17065"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17065","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"type":"print","value":"0385-2407"},{"type":"electronic","value":"1346-8138"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"2023-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}