{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:58:18Z","timestamp":1782316698139,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The combination of BRAF kinase inhibitors (BRAFis) and MEK kinase inhibitors (MEKis) is one of the most promising chemotherapy regimens in the treatment of BRAF\u2010mutant melanoma. Although BRAFi plus MEKi combined therapy is widely used for the treatment of BRAF\n                    <jats:sup>V600<\/jats:sup>\n                    \u2010mutated melanoma, the incidence of uveitis caused by BRAFi plus MEKi is limited. In this report, we described five cases (two men and three women) of Vogt\u2010Koyanagi\u2010Harada (VKH) disease\u2010like uveitis in melanoma patients who received BRAFi plus MEKi combined therapy. Of note, all the patients had the HLA\u2010DRB1*04 haplotype, which is frequently detected in VKH\u2010like non\u2010infectious uveitis. On the other hand, among BRAFi plus MEKi\u2010treated patients who did not develop VKH disease\u2010like uveitis, only one of five (20%) patients had the HLA\u2010DRB1*04 haplotype. Collectively, BRAFi\/MEKi might induce severe VKH disease\u2010like uveitis in melanoma patients with the HLA\u2010DRB1*04 haplotype.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17082","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T05:30:05Z","timestamp":1702963805000},"page":"854-857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<scp>Vogt\u2010Koyanagi\u2010Harada<\/scp>\n                    disease\u2010like uveitis after drug therapy including\n                    <scp>BRAF<\/scp>\n                    \/\n                    <scp>MEK<\/scp>\n                    inhibitors in melanoma patients with\n                    <scp>HLA\u2010DRB1<\/scp>\n                    *04"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3337-5657","authenticated-orcid":false,"given":"Ryo","family":"Amagai","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manami","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tamabuchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Kambayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihide","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708539"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx176"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091342"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.12.021"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15688"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.05.031"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad183"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2019-000491"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000505"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/IIO.0000000000000434"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.911"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524021666211027092124"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14273"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273948.2020.1781902"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.07.016"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T11:15:10Z","timestamp":1763032510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,19]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/1346-8138.17082"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17082","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,19]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}