{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:29:18Z","timestamp":1787938158761,"version":"build-2784847793"},"reference-count":6,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 73\u2010year\u2010old man with diabetes mellitus was referred to our department for ultraviolet treatment for erythematous skin lesions with itching. On dipeptidyl peptidase\u20104 inhibitor (DPP\u20104i) sitagliptin (Januvia\u00ae) for diabetes mellitus, the erythematous skin lesions appeared and spread to the whole body. At the initial visit, erythema multiforme\u2010like skin lesions with crusts were observed on the trunk and extremities, and the patient was suspected to have drug eruption. Histopathology demonstrated eosinophilic infiltration in the superficial dermis and inflammatory cell infiltration in the epidermis. Sitagliptin was discontinued, and erythematous lesions improved with oral prednisolone. Thereafter the patient was treated with phototherapy and \u00a0betamethasone sodium phosphate infusion for residual prurigo. However, blistering skin lesions appeared 5\u2009months later. Histopathological findings were subepidermal blisters with eosinophilic abscess, and bullous pemphigoid was suspected. CLEIAs for autoantibodies to desmoglein 1 (Dsg1), Dsg3 and BP180 were negative. Direct immunofluorescence showed linear depositions of immunoglobulin G (IgG) and C3 at the epidermal basement membrane zone, and indirect immunofluorescence detected IgG anti\u2010epidermal basement membrane zone antibodies, reacting with the dermal side of 1M NaCl\u2010split normal human skin. IgG antibodies reacted with 200\u2009kDa laminin \u03b31 (p200) by immunoblotting using dermal extracts. These results indicated that this patient was diagnosed with anti\u2010laminin \u03b31 (p200) pemphigoid developed after DPP\u20104i administration. Although reports of DPP\u20104i\u2010related bullous pemphigoid have accumulated, cases of anti\u2010laminin \u03b31 (p200) pemphigoid developed after DPP\u20104i administration are rarely reported.<\/jats:p>","DOI":"10.1111\/1346-8138.17105","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T08:49:54Z","timestamp":1705049394000},"page":"869-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A case of anti\u2010laminin \u03b31 (p200) pemphigoid developed after dipeptidyl peptidase\u20104 inhibitor administration"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-0280","authenticated-orcid":false,"given":"Kahori","family":"Nakatani","sequence":"first","affiliation":[{"name":"Department of Dermatology Kansai Medical University Kori Hospital  Neyagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Noborio","sequence":"additional","affiliation":[{"name":"Department of General Medicine Kansai Medical University Kori Hospital  Neyagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4978-0039","authenticated-orcid":false,"given":"Yuki","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Pref Osaka Saiseikai Izuo Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ueki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University  Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-9071","authenticated-orcid":false,"given":"Takahiro","family":"Kiyohara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Medical Center  Moriguchi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-3255","authenticated-orcid":false,"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809230106"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14629"},{"key":"e_1_2_6_4_1","first-page":"128","article-title":"A case of anti\u2010laminin gamma\u20101 pemphigoid presented with rosette\u2010, dyshidrosis\u2010, erythema multiforme\u2010, and folliculitis\u2010like eruptions","volume":"43","author":"Yamazaki Y","year":"2021","journal-title":"Pract Dermatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15227"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15126"},{"key":"e_1_2_6_7_1","first-page":"219","article-title":"A case of anti\u2010laminin gamma\u20101 pemphigoid after long\u2010term oral DPP4 inhibitor therapy (in Japanese)","volume":"63","author":"Nomura F","year":"2021","journal-title":"Rinsho Derma"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.17105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T11:15:37Z","timestamp":1763032537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.17105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,12]]},"references-count":6,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/1346-8138.17105"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.17105","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,12]]},"assertion":[{"value":"2023-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}