{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:16:19Z","timestamp":1791994579048,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304062"],"award-info":[{"award-number":["82304062"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The therapeutic strategy for the treatment of pemphigus vulgaris (PV) still needs optimization because of the multiple deficiencies of glucocorticoid and rituximab. Ofatumumab, another CD20 monoclonal antibody administrated subcutaneously, provides a possible alternative option. In this study, three patients experienced PV relapse after clinical remission induced by rituximab. With written informed consent, they received an ofatumumab (20\u2009mg) subcutaneous injection twice (2\u2009weeks apart) in combination with a prednisone dose adjusted according to their weight and disease severity. Over the 24\u2010week observation, two of three patients achieved lesion clear\u2010up under prednisone (0.2\u2009mg\/kg per day), and the other patient's pemphigus disease area index dropped from 39 to 3 with prednisone (15\u2009mg\/day). The anti\u2010desmoglein antibody levels and CD19\n                    <jats:sup>+<\/jats:sup>\n                    B cell counts declined compared to those at baseline. No severe adverse events were observed within the 24\u2010week follow\u2010up. In summary, we propose a protocol of ofatumumab for patients with refractory PV and report positive treatment outcomes of three patients who received this regimen.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17108","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:06:16Z","timestamp":1706673976000},"page":"1026-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ofatumumab subcutaneous injection successfully treated patients with pemphigus vulgaris relapse post rituximab"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3271-2772","authenticated-orcid":false,"given":"Xiwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3013-9655","authenticated-orcid":false,"given":"Yue","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9612-3903","authenticated-orcid":false,"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Outpatient, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2628-7713","authenticated-orcid":false,"given":"Jinqiu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Outpatient, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7060-254X","authenticated-orcid":false,"given":"Xingli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2205-1362","authenticated-orcid":false,"given":"Yiyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-2794","authenticated-orcid":false,"given":"Yuxi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6851-5944","authenticated-orcid":false,"given":"Mi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2884","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology &amp; Rare Disease Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31778-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.02.021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16561"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.06.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028564"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.02.308"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2020.05.034"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-021-00895-w"},{"key":"e_1_2_7_10_1","unstructured":"Kesimpta 20 mg solution for injection in pre\u2010filled pen \u2010 Summary of Product Characteristics (SmPC) \u2013 (emc) [Internet].2021\u00a0March 26. 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