{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:31:04Z","timestamp":1792812664518,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris (AV) exacerbation after whey protein (WP) consumption remains inconclusive among experts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between WP consumption and acne severity in men with acne.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A noninferiority trial was conducted in men with mild to moderate facial and\/or truncal acne. After randomization, participants in an intervention group took daily WP 30 g with a non\u2010WP nutritional supplement 18\u2009g (WP group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925), while the control group took a non\u2010WP nutritional supplement 46\u2009g (non\u2010WP group,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924). At each follow\u2010up appointment, investigators evaluated acne count (total acne lesions, comedonal lesions, and inflammatory lesions) and severity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine participants had a mean age of 19.7\u2009years (standard deviation [SD], 0.9) and 20.3\u2009years (SD, 1.4) in the WP and non\u2010WP groups, respectively. The mean differences in the facial and truncal total acne lesions for the WP and non\u2010WP group were \u22125.99 (95% confidence interval [CI], \u221213.18 to 1.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.09) and \u22122.18 (95% CI, \u221211.83 to 7.48,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.65), respectively. For severity changes, only one (4.3%) participant in the non\u2010WP group reported an increase in the Investigator Global Assessment scale of at least two levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this 6\u2010month trial, men with acne who undertook WP supplementation showed a noninferior difference in the changes in total acne lesions and severity of facial and truncal acne compared with the non\u2010WP group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1346-8138.17109","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T03:49:48Z","timestamp":1706672988000},"page":"1022-1025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Whey protein and male acne: A double\u2010blind, randomized controlled trial"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9044-6951","authenticated-orcid":false,"given":"Kittithorn","family":"Sompochpruetikul","sequence":"first","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanon","family":"Khongcharoensombat","sequence":"additional","affiliation":[{"name":"Division of Clinical Nutrition, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuda","family":"Chongpison","sequence":"additional","affiliation":[{"name":"Biostatistics Excellence Centre, Research Affairs, The Skin and Allergy Research Unit, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wattanai","family":"Rittirongwattana","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2628-0894","authenticated-orcid":false,"given":"Pravit","family":"Asawanonda","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nopadon","family":"Noppakun","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-0523","authenticated-orcid":false,"given":"Chanat","family":"Kumtornrut","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"},{"name":"Division of Dermatology, Department of Medicine King Chulalongkorn Memorial Hospital, The Thai Red Cross Society  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0370"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345102"},{"key":"e_1_2_10_4_1","first-page":"70","article-title":"Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes","volume":"90","author":"Silverberg 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