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We conducted a comprehensive and unbiased investigation of comorbidities in patients with psoriasis and explored the pattern of association between comorbidities. A nationwide population\u2010based study included 384\u2009914 patients with psoriasis and 384\u2009914 matched controls between 2011 and 2021. We used automated mass screening of all diagnostic codes to identify psoriasis\u2010associated comorbidities and applied association rule analysis to explore the patterns of comorbidity associations in patients with psoriasis. Patients with psoriasis had an increased risk of autoimmunity\u2010related diseases such as inflammatory arthritis, Crohn's disease, type 1 diabetes, and acute myocardial infarction. The comorbidities of patients with psoriasis with a history of cardiovascular events demonstrated strong interrelationships with other cardiovascular risk factors including type 2 diabetes mellitus, essential hypertension, and dyslipidemia. We also found comorbidities, such as malignant skin tumors and kidney and liver diseases, which could have adverse effects of anti\u2010psoriasis therapy. In contrast, patients with psoriasis showed a decreased association with upper respiratory tract infection. Our results imply that comorbidities in patients with psoriasis are associated with the systemic inflammation of psoriasis and the detrimental effects of its treatment. Furthermore, we found patterns of associations between the cardiovascular risk factors and psoriasis. Mass screening and association analyses using large\u2010scale databases can be used to investigate impartially the comorbidities of psoriasis and other diseases.<\/jats:p>","DOI":"10.1111\/1346-8138.17121","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T13:13:50Z","timestamp":1707743630000},"page":"539-551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Automated mass screening and association rules analysis for comorbidities of psoriasis: A population\u2010based case\u2013control study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2223-1606","authenticated-orcid":false,"given":"Bo Ri","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital Seoul National University College of Medicine  Seongnam 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