{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:53Z","timestamp":1787013593186,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association between uveitis and spondyloarthropathy (SpA)\u2010related conditions is well\u2010established. However, evidence describing the link between uveitis and psoriasis, and psoriasis without concomitant SpA\u2010related conditions is scarce and conflicting. This large\u2010scale population\u2010based study sought to describe the prevalence and features of uveitis among psoriasis patients in Israel as well as investigating the risk for uveitis in different subgroups of psoriasis patients compared to the general population. We conducted a retrospective study utilizing the electronic database of the Meuhedet Health Maintenance Organization. The study included all patients diagnosed with psoriasis between 2000 and 2020, each patient was matched with four controls based on age, sex, place of residence, and index date. Logistic regression models were employed to assess the association between psoriasis and uveitis while adjusting for the presence of SpA\u2010related conditions. A total of 61\u2009003 psoriasis patients and 244\u2009012 matched controls were included. The prevalence of uveitis was 1.3% versus 1.1% respectively (OR\u2009\u20091.12; 95% CI 1.10\u20131.30;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). When adjusting to psoriasis severity, concurrent SpA, and psoriasis treatment no significant association was found. The rates of uveitis among psoriasis patients with concurrent SpA\u2010related conditions was 3.2% compared to 1.4% in controls without psoriasis or SpA (OR\u20092.38; 95% CI 2.00\u20132.83;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), while in psoriasis patients without SpA, the rate of uveitis was 1.0% and was similar to controls. Although crude rates of uveitis were higher in patients with severe psoriasis compared to mild psoriasis (2.1% vs. 1.1%), after adjustment, no significant association compared to controls was found in either group. Our findings suggest that the positive association between psoriasis and uveitis is primarily mediated by the coexistence of other SpA\u2010related conditions. These findings imply the presence of a shared pathogenetic mechanism and set the direction for a phenotypic\u2010targeted screening strategy.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.17123","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:05:27Z","timestamp":1706673927000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unraveling the connection: Uveitis prevalence and risk factors in psoriasis patients \u2014 a population\u2010based study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0412-1729","authenticated-orcid":false,"given":"Yonatan Shneor","family":"Patt","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niv","family":"Ben\u2010Shabat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassem","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Department of Gastroenterology Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"David","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Patt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"The Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoav","family":"Elizur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uria","family":"Shani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galia","family":"Zacay","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Meuhedet Health Maintenance Organization  Tel Aviv Israel"},{"name":"Department of Family Medicine, Sackler Faculty of Medicine University of Tel Aviv  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1404-8027","authenticated-orcid":false,"given":"Abdulla","family":"Watad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"},{"name":"Section of Musculoskeletal Disease, NIHR Leeds Musculoskeletal Biomedical Research Unit Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Amital","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine B &amp; Zabludowicz Center for Autoimmune Diseases Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Sackler Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv 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